68809-64-3

Usage

Uses

Used in Pharmaceutical Research and Development:
Ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate is utilized as a building block in the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic benefits.
Used in Neurological Disorder Treatment:
In the medical field, ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate is employed as a component in the development of drugs aimed at treating neurological disorders, leveraging its potential neuroprotective properties.
Used as an Anticonvulsant:
ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate is also used in the formulation of anticonvulsant medications, capitalizing on its capacity to help manage conditions characterized by seizures.
Used in Crop Protection:
Ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate is studied for its potential as an insecticide, indicating its use in the agricultural sector for the development of effective crop protection products.
Used in Organic Synthesis:
In the chemical industry, ethyl 1,4-diMethyl-1H-pyrazole-5-carboxylate serves as an important intermediate in organic synthesis, facilitating the production of a range of chemical products.

Upstream product

• 64-17-5 ethanol 
• 7339-53-9 methyl hydrazine hydrochloride 
• 121781-57-5 (E)-1,1,1-trichloro-4-ethoxy-3-methylbut-3-en-2-one 
• 6076-12-6 ethyl 4-methyl-1H-pyrazole-5-carboxylate 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 186581-53-3 diazomethane 
• 4341-76-8 Ethyl 2-butynoate 

Downstream Products

• 13745-58-9 1,4-dimethyl-5-pyrazole carboxylic acid 
• 1607024-80-5 2-(1,4-dimethyl-1H-pyrazol-5-yl)acetonitrile 
• 89202-85-7 N-Phenyl-1,4-dimethylpyrazole-5-carboxamide 

Relevant academic research and scientific papers

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

AMIDO COMPOUNDS AS AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

Haloacetylated enol ethers. 11 [16]. Synthesis of 1-methyl- and 1- phenyl pyrazole-3(5)-ethyl esters. A one-pot procedure

A one-pot synthesis of 1-methyl- and 1-phenylpyrazole-3(5)-ethyl esters 2,3a-e by the cyclocondensation of β-alkoxyvinyl trichloromethyl ketones 1a- e with methyl and phenyl hydrazine hydrochloride under mild conditions, is reported. A study using compounds la-e with different substituents proved that these are versatile building blocks for the synthesis of pyrazole derivatives, having a 3(5)-ethoxycarbonyl substituent in good yields (60- 89%). The hydrazine and β-alkoxyvinyl trichloromethyl ketone substituent effects on the reaction regiochemistry on the formation of the 1,3- and 1,5- isomer were observed.