1374515-48-6Relevant academic research and scientific papers
Heck-type cross-dehydrogenative coupling reactions of indolizines at the 3-position with electron-deficient alkenes through palladium-catalyzed C-H activation
Hu, Huayou,Liu, Yun,Zhong, Hao,Zhu, Yulan,Wang, Chao,Ji, Min
supporting information; experimental part, p. 884 - 888 (2012/07/03)
A cross-dehydrogenative coupling reaction of indolizines with electron-deficient alkenes for the synthesis of 3-alkenyl-substituted indolizines has been reported. The reaction takes place at the 3-position selectively through palladium-catalyzed C-H activation, following a Heck-type cross-coupling reaction under mild and ligand-free conditions. Furthermore, the reaction mechanism of the PdII/Pd0 catalytic pathway was also confirmed by 1H NMR spectroscopy.
