1374516-07-0 Usage
Uses
Used in Pharmaceutical Industry:
TUG 891 is used as a therapeutic agent for the treatment of type 2 diabetes and metabolic diseases. Its agonistic action on GPR120 receptor helps in improving glucose and lipid metabolism, making it a promising candidate for managing these conditions.
Used in Research and Development:
TUG 891 is also used as a research tool in the field of endocrinology and metabolism. It aids scientists in understanding the role of GPR120 receptor in glucose and lipid homeostasis, as well as its potential as a therapeutic target for related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1374516-07-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,4,5,1 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1374516-07:
(9*1)+(8*3)+(7*7)+(6*4)+(5*5)+(4*1)+(3*6)+(2*0)+(1*7)=160
160 % 10 = 0
So 1374516-07-0 is a valid CAS Registry Number.
1374516-07-0Relevant articles and documents
Discovery of a potent and selective GPR120 agonist
Shimpukade, Bharat,Hudson, Brian D.,Hovgaard, Christine Kiel,Milligan, Graeme,Ulven, Trond
, p. 4511 - 4515 (2012/08/13)
GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. Further investigation is however hindered by the lack of suitable receptor modulators. Screening of FFA1 ligands provided a lead with moderate activity on GPR120 and moderate selectivity over FFA1. Optimization led to the discovery of the first potent and selective GPR120 agonist.
