TUG 891

Base Information

Chemical Name:TUG 891
CAS No.:1374516-07-0
Molecular Formula:C23H21FO3
Molecular Weight:364.416
Hs Code.:
Mol file:1374516-07-0.mol

Synonyms:TUG 891

Suppliers and Price of TUG 891

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TUG891
100mg
$ 1025.00

Tocris
TUG891 ≥99%(HPLC)
50
$ 806.00

Tocris
TUG891 ≥99%(HPLC)
10
$ 195.00

Sigma-Aldrich
TUG-891 ≥98% (HPLC)
5mg
$ 87.50

Sigma-Aldrich
TUG-891 ≥98% (HPLC)
25mg
$ 355.00

Medical Isotopes, Inc.
TUG891
10 mg
$ 640.00

Medical Isotopes, Inc.
TUG891
100 mg
$ 1475.00

DC Chemicals
TUG891 >98%
250 mg
$ 800.00

DC Chemicals
TUG891 >98%
100 mg
$ 450.00

Crysdot
TUG-891 95+%
25mg
$ 228.00

Total 15 raw suppliers

Chemical Property of TUG 891

Chemical Property:

Boiling Point:540.8±50.0 °C(Predicted)
PKA:4.70±0.10(Predicted)
PSA：46.53000
Density:1.199±0.06 g/cm3(Predicted)
LogP:5.39730
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

TUG891 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses TUG 891 is a potent and selective GPR120 agonist as a new potential target for treatment of type 2 diabetes and metabolic diseases.

Technology Process of TUG 891

There total 3 articles about TUG 891 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1374516-35-4
methyl 3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoate

: 1374516-07-0
3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm300215x

Reference yield:

: 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester

: 1374516-07-0
3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 20 h / 75 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; potassium iodide; lithium hydroxide; In tetrahydrofuran; water; acetone; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/jm300215x

Reference yield:

: 857276-61-0
5-fluoro-2-bromobenzyl chloride

: 1374516-07-0
3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 20 h / 75 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; potassium iodide; lithium hydroxide; In tetrahydrofuran; water; acetone; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/jm300215x