1374516-18-3

Upstream product

• 1236109-77-5 methyl 3-(4-((2-iodobenzyl)oxy)phenyl)propanoate 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 59473-45-9 2-(chloromethyl)iodobenzene 

Downstream Products

• 1374515-89-5 3-(4-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid 

Relevant academic research and scientific papers

Discovery of a potent and selective GPR120 agonist

GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. Further investigation is however hindered by the lack of suitable receptor modulators. Screening of FFA1 ligands provided a lead with moderate activity on GPR120 and moderate selectivity over FFA1. Optimization led to the discovery of the first potent and selective GPR120 agonist.