1374584-45-8

Basic information

• Product Name: 1-(4-methoxybenzyl)-3,5-bis(trifluoromethyl)benzene
• Synonyms: 1-(4-methoxybenzyl)-3,5-bis(trifluoromethyl)benzene
• CAS NO: 1374584-45-8
• Molecular Weight: 334.261
• Mol File: 1374584-45-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxybenzyl)-3,5-bis(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxybenzyl)-3,5-bis(trifluoromethyl)benzene(1374584-45-8)
• EPA Substance Registry System: 1-(4-methoxybenzyl)-3,5-bis(trifluoromethyl)benzene(1374584-45-8)

Safety Data

• Hazardous Substances Data: 1374584-45-8(Hazardous Substances Data)

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 32247-96-4 3,5-bis(trifluoromethyl)benzyl bromide 

Relevant articles and documents

Selective Late-Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes

A selective reductive monodefluorination reaction of trifluoromethyl arenes was developed. Mediated by magnesium metal, various difluoromethylated aromatics were accessed at room temperature in the presence of acetic acid. This protocol shows tolerance to a wide range of functional groups and it was applicable in late-stage hydrodefluorination of complex pharmaceutical compounds, affording the corresponding CF2H analogues and their deuterated (CF2D) counterparts.