1374637-68-9Relevant academic research and scientific papers
Acid-mediated sulfonylation of arylethynylene bromides with sodium arylsulfinates: Synthesis of (: E)-1,2-bis(arylsulfonyl)ethylenes and arylacetylenic sulfones
Dai, Chenshu,Wang, Junqi,Deng, Siqi,Zhou, Candong,Zhang, Wenhe,Zhu, Qiuhua,Tang, Xiaodong
, p. 36112 - 36116 (2017)
A solvent-dependent sulfonylation of arylethynylene bromides with sodium arylsulfinates has been developed. The (E)-1,2-bis(arylsulfonyl)ethylenes were formed in DMSO, while the arylacetylenic sulfones were obtained in toluene. Utilizing simple and readily available starting materials, the sulfonylation products were generated with good selectivities and yields without the need for a metal catalyst or oxidant.
Synthetic method of alkynyl sulfone derivative
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Paragraph 0022; 0023; 0024; 0025; 0026; 0027-0029; 0030, (2017/05/13)
The invention provides a synthetic method of an alkynyl sulfone derivative. The method is characterized in that alkynyl sulfone derivative is obtained through a reaction of alkynyl bromide and organic sodium sulfinate in the presence of an organic solvent and a strong acid used as a catalyst; and the organic solvent is one or more of toluene, chloroform, 1,2-dichloroethane, 1,4-dioxane and tetrahydrofuran. The method has the advantages of no use of complex reaction substrates or strong oxidants, simple and easily available reaction raw materials, safety and simplicity in reaction operation, environmentally-friendly reaction process, good substrate applicability, good function group tolerance, and high separation yield under preferable conditions and the alkynyl sulfone derivative synthesized through the method widely exists in natural products and medicine molecules, and also can be used as a very effective alkynylation reagent.
Direct cross-coupling of aryl alkynyliodines with arylsulfinic acids leading to alkynyl sulfones under catalyst-free conditions
Wang, Leilei,Wei, Wei,Yang, Daoshan,Cui, Huanhuan,Yue, Huilan,Wang, Hua
supporting information, p. 4799 - 4802 (2017/11/27)
A facile and efficient one-pot method has been developed for the construction of alkynyl sulfones via direct cross-coupling reaction of aryl alkynyliodines and arylsulfinic acids. The present transformation could be accomplished under catalyst- and additive-free conditions, providing a series of alkynyl sulfones in moderate to good yields with favorable functional group tolerance.
