1374753-83-9Relevant academic research and scientific papers
Bis(cycloocta-1,5-diene)nickel-Catalyzed Carbon Dioxide Fixation for the Stereoselective Synthesis of 3-Alkylidene-2-indolinones
Miao, Bukeyan,Zheng, Yangguangyan,Wu, Penglin,Li, Suhua,Ma, Shengming
, p. 1691 - 1707 (2017/05/22)
A bis(cycloocta-1,5-diene)nickel-catalyzed highly regio- and (E)-stereoselective hydrocarboxylation of 2-alkynylanilines under very mild conditions has been developed to afford (E)-[2-(o-aminophenyl)]acrylic acids, which could easily be converted to (E)-3
Cyclic Anti-Azacarboxylation of 2-Alkynylanilines with Carbon Dioxide
Miao, Bukeyan,Li, Suhua,Li, Gen,Ma, Shengming
supporting information, p. 2556 - 2559 (2016/07/06)
Direct anti-azacarboxylation of 2-alkynylanilines with CO2 mediated by ZnEt2 was observed to afford indole-3-carboxylic acids, a class of important compounds for the synthesis of many biologically active compounds, efficiently under 1 atm of CO2. The readily available nature of the different starting materials and tolerance of various functional groups provide vast opportunities for the efficient construction of diversified libraries for bioactive compounds listed in Figure 1. As an example, this methodology has been applied to the synthesis of Lotronex, a drug molecule used for the treatment of irritable bowel syndrome.
Quadri-synergetic effect for highly effective carbon dioxide fixation and its application to indoloquinolinone
Li, Suhua,Ma, Shengming
supporting information, p. 2387 - 2394,8 (2020/08/31)
The first copper-catalyzed cyclic anti-nucleometallation-carboxylation of 2-alkynylanilines with carbon dioxide in the presence of dimethylzinc (ZnMe 2) and cesium fluoride (CsF) for the effective synthesis of indolyl-3-carboxylic acids and indolodihydropyran-2-one is described. Through a mechanistic study, it is unveiled that the metal ions Cu2+, Zn 2+, Cs+ and F- are working together for this CO2-based highly efficient carboxylation. Copyright
Synthesis of 3-carboxylated indoles through a tandem process involving cyclization of 2-ethynylanilines followed by CO2 fixation in the absence of transition metal catalysts
Inamoto, Kiyofumi,Asano, Narumi,Nakamura, Yuka,Yonemoto, Misato,Kondo, Yoshinori
supporting information; experimental part, p. 2622 - 2625 (2012/07/14)
In this study, a facile synthesis of 3-carboxylated indoles involving a tandem-type cyclization of 2-ethynylanilines and subsequent CO2 fixation at the 3-position of the indole ring is realized. The reaction proceeds efficiently at 65 °C under
