1374820-26-4

Basic information

• Product Name: C₁₈H₁₉Cl₂N₃OS
• Synonyms: C₁₈H₁₉Cl₂N₃OS
• CAS NO: 1374820-26-4
• Molecular Weight: 396.34
• Mol File: 1374820-26-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₉Cl₂N₃OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₉Cl₂N₃OS(1374820-26-4)
• EPA Substance Registry System: C₁₈H₁₉Cl₂N₃OS(1374820-26-4)

Safety Data

• Hazardous Substances Data: 1374820-26-4(Hazardous Substances Data)

Upstream product

• 1747-60-0 6-methoxybenzothiazol-2-ylamine 
• 2605-14-3 2-chloro-6-(methyloxy)-1,3-benzothiazole 
• 1374820-44-6 C₁₆H₂₃N₃O₃S 
• 104-94-9 4-methoxy-aniline 
• 20174-70-3 2-hydrazinyl-6-methoxybenzo[d]thiazole 
• 1329812-06-7 C₁₁H₁₅N₃OS 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Relevant articles and documents

Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives

In this study, a novel benzothiazol- and benzooxazol-2-amine scaffold with antibacterial activity was designed and synthesized. Preliminary structure-activity relationship analysis displayed that compound 8t with a 5,6-difluorosubstituted benzothiazole was found to be a potent inhibitor of Gram-positive pathogens, and exhibited some potential against drug-resistant bacteria and without cytotoxicity in therapeutic concentrations. In addition, molecular docking studies indicated that Staphylococcus aureus methionyl-tRNA synthetase might be the possible target of these compounds. Taken together, the present study provides an effective entry to the synthesis of a good lead for subsequent optimization and a new small molecule candidate drug for antibacterial therapeutics.