Welcome to LookChem.com Sign In|Join Free

CAS

  • or

2605-14-3

Post Buying Request

2605-14-3 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

2605-14-3 Usage

Chemical Properties

White solid

Check Digit Verification of cas no

The CAS Registry Mumber 2605-14-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,0 and 5 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2605-14:
(6*2)+(5*6)+(4*0)+(3*5)+(2*1)+(1*4)=63
63 % 10 = 3
So 2605-14-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClNOS/c1-11-5-2-3-6-7(4-5)12-8(9)10-6/h2-4H,1H3

2605-14-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H32770)  2-Chloro-6-methoxybenzothiazole, 97%   

  • 2605-14-3

  • 1g

  • 883.0CNY

  • Detail
  • Alfa Aesar

  • (H32770)  2-Chloro-6-methoxybenzothiazole, 97%   

  • 2605-14-3

  • 5g

  • 3057.0CNY

  • Detail
  • Aldrich

  • (667331)  2-Chloro-6-methoxybenzothiazole  97%

  • 2605-14-3

  • 667331-1G

  • 734.76CNY

  • Detail
  • Aldrich

  • (667331)  2-Chloro-6-methoxybenzothiazole  97%

  • 2605-14-3

  • 667331-5G

  • 2,552.94CNY

  • Detail

2605-14-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-6-methoxy-1,3-benzothiazole

1.2 Other means of identification

Product number -
Other names benzothiazole,2-chloro-6-methoxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2605-14-3 SDS

2605-14-3Synthetic route

6-methoxybenzothiazol-2-ylamine
1747-60-0

6-methoxybenzothiazol-2-ylamine

2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

Conditions
ConditionsYield
With polyethylene glycol; copper dichloride; isopentyl nitrite In acetonitrile at 65℃; for 3h;83.5%
Stage #1: 6-methoxybenzothiazol-2-ylamine With sodium nitrite In ethanol at 15℃; for 3h;
Stage #2: With hydrogenchloride; copper(l) chloride In water at 60℃; for 2h;
78.1%
Stage #1: 6-methoxybenzothiazol-2-ylamine With hydrogenchloride; sodium nitrite In ethanol; water at 15℃; for 3h;
Stage #2: With copper(l) chloride In ethanol; water at 60℃; for 2h;
69.5%
carbon disulfide
75-15-0

carbon disulfide

4-methoxy-aniline
104-94-9

4-methoxy-aniline

2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

Conditions
ConditionsYield
(i) KSCN, Br2, (ii) aq. NaOH, (iii) /BRN= 1098293/, (iv) SO2Cl2; Multistep reaction;
diazotized 6-methoxy-benzothiazol-2-ylamine

diazotized 6-methoxy-benzothiazol-2-ylamine

2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

Conditions
ConditionsYield
With hydrogenchloride; copper(l) chloride
2-hydrazinyl-6-methoxybenzo[d]thiazole
20174-70-3

2-hydrazinyl-6-methoxybenzo[d]thiazole

2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

Conditions
ConditionsYield
With thionyl chloride at 50℃; for 2h;
4-methoxy-aniline
104-94-9

4-methoxy-aniline

2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine; acetic acid / 0.5 h / 0 °C
2: hydrazine hydrochloride; hydrazine hydrate / ethylene glycol / 2 h / 140 °C
3: thionyl chloride / 2 h / 50 °C
View Scheme
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

2-chloro-6-hydroxy-benzothiazole
2591-16-4

2-chloro-6-hydroxy-benzothiazole

Conditions
ConditionsYield
With boron trichloride; tetra-(n-butyl)ammonium iodide In n-heptane; dichloromethane at -78 - 20℃;95%
With aluminum (III) chloride In toluene at 110℃; for 1.5h;93%
With boron tribromide In dichloromethane at -10 - 25℃; for 64h;86%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

aniline
62-53-3

aniline

6-methoxy-N-phenylbenzo[d]thiazol-2-amine
539811-75-1

6-methoxy-N-phenylbenzo[d]thiazol-2-amine

Conditions
ConditionsYield
at 100℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;90%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

phenylacetylene
536-74-3

phenylacetylene

C16H11NOS
1440509-66-9

C16H11NOS

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 20℃; for 33h; Catalytic behavior; Sonogashira Cross-Coupling; Inert atmosphere; Schlenk technique;87%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

4-(6'-methoxy-benzothiazole-2'-yloxy)-1-oxyl-2,2,6,6-tetramethylpiperidine

4-(6'-methoxy-benzothiazole-2'-yloxy)-1-oxyl-2,2,6,6-tetramethylpiperidine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20℃;84.6%
With sodium hydride In N,N-dimethyl-formamide at 20℃;84.6%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

potassium vinyltrifluoroborate

potassium vinyltrifluoroborate

C10H9NOS

C10H9NOS

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; triethylamine In isopropyl alcohol for 16h; Reflux; Inert atmosphere;83%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

(R)-phenylglycinol hydrochloride

(R)-phenylglycinol hydrochloride

(R)-2-((6-methoxybenzo[d]thiazol-2-yl)amino)-2-phenylethan-1-ol

(R)-2-((6-methoxybenzo[d]thiazol-2-yl)amino)-2-phenylethan-1-ol

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-benzene at 195℃; for 48h;82%
1-(1-methylethyl)piperazine
4318-42-7

1-(1-methylethyl)piperazine

2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

2-(4-isopropylpiperazin-1-yl)-6-methoxybenzothiazole hydrochloride

2-(4-isopropylpiperazin-1-yl)-6-methoxybenzothiazole hydrochloride

Conditions
ConditionsYield
Stage #1: 1-(1-methylethyl)piperazine; 2-chloro-6-(methyloxy)-1,3-benzothiazole at 120℃; for 2h;
Stage #2: With sodium hydrogencarbonate In water; ethyl acetate
Stage #3: With hydrogenchloride In water; ethyl acetate
80%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

sodium methylate
124-41-4

sodium methylate

2-methoxy-6-methoxybenzothiazole
3507-19-5

2-methoxy-6-methoxybenzothiazole

Conditions
ConditionsYield
In methanol at 70℃; for 12h; Inert atmosphere;77.8%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

tert-butyl 3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate
960535-17-5

tert-butyl 3-((pyridin-3-yloxy)methyl)piperazine-1-carboxylate

C23H28N4O4S
1609464-80-3

C23H28N4O4S

Conditions
ConditionsYield
With palladium diacetate; triphenylphosphine; sodium t-butanolate In toluene at 110℃;73%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

(R)-2-((R)-amino(phenyl)methyl)-3-methylbutan-1-ol hydrochloride

(R)-2-((R)-amino(phenyl)methyl)-3-methylbutan-1-ol hydrochloride

C20H22N2OS

C20H22N2OS

Conditions
ConditionsYield
Stage #1: 2-chloro-6-(methyloxy)-1,3-benzothiazole; (R)-2-((R)-amino(phenyl)methyl)-3-methylbutan-1-ol hydrochloride With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-benzene at 195℃;
Stage #2: With methanesulfonyl chloride; triethylamine at 0℃;
Stage #3: With isopropyl alcohol In dichloromethane at 40℃;
71%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

Cyclopropylamine
765-30-0

Cyclopropylamine

C11H12N2OS

C11H12N2OS

Conditions
ConditionsYield
With triethylamine In 1-methyl-pyrrolidin-2-one at 100℃; for 18h; Inert atmosphere;71%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-phenylamine
573711-38-3

3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-phenylamine

3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-phenyl-(5-methoxy-benzothiazol-2-yl)-amine

3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-phenyl-(5-methoxy-benzothiazol-2-yl)-amine

Conditions
ConditionsYield
In ethanol at 160℃; for 0.333333h;68.6%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

2-deuterio-6-methoxy-1,3-benzothiazole
1610958-34-3

2-deuterio-6-methoxy-1,3-benzothiazole

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; d8-isopropanol; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 100℃; for 2.5h; Inert atmosphere; Microwave irradiation;68%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

tert-butyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
250275-15-1, 1256094-14-0

tert-butyl (3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

5-(6-methoxybenzothiazol-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

5-(6-methoxybenzothiazol-2-yl)hexahydropyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 18h; Inert atmosphere;64%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

aniline
62-53-3

aniline

6-methoxy-N-(6-methoxybenzo[d]thiazol-2-yl)-N-phenylbenzo[d]thiazol-2-amine

6-methoxy-N-(6-methoxybenzo[d]thiazol-2-yl)-N-phenylbenzo[d]thiazol-2-amine

Conditions
ConditionsYield
at 100℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;64%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

7-bromo-2-chloro-6-methoxybenzo[d]thiazole
911056-05-8

7-bromo-2-chloro-6-methoxybenzo[d]thiazole

Conditions
ConditionsYield
With N-Bromosuccinimide In 1-methyl-pyrrolidin-2-one at 20 - 75℃; for 24h;60%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

2-(difluoromethoxy)-7-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxaline

2-(difluoromethoxy)-7-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxaline

2-(2-(difluoromethoxy)-7-methylquinoxalin-5-yl)-6-methoxybenzo[d]thiazole

2-(2-(difluoromethoxy)-7-methylquinoxalin-5-yl)-6-methoxybenzo[d]thiazole

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In ethanol; toluene at 20 - 120℃; for 0.5h; Suzuki-Miyaura Coupling; Inert atmosphere; Sealed tube; Microwave irradiation;55.1%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

Allyl acetate
591-87-7

Allyl acetate

cesium 2-((1-methylcyclohexyl)oxy)-2-oxoacetate

cesium 2-((1-methylcyclohexyl)oxy)-2-oxoacetate

2-(6-methoxybenzo[d]thiazol-2-yl)-3-(1-methylcyclohexyl)propyl acetate

2-(6-methoxybenzo[d]thiazol-2-yl)-3-(1-methylcyclohexyl)propyl acetate

Conditions
ConditionsYield
With (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine In dimethyl sulfoxide at 35℃; for 24h; Sealed tube; Inert atmosphere; Irradiation; regioselective reaction;53%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

3-amino-4-pyrazolecarboxylic acid ethyl ester
6994-25-8

3-amino-4-pyrazolecarboxylic acid ethyl ester

3-amino-1-(6-methoxybenzothiazol-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester
1355241-15-4

3-amino-1-(6-methoxybenzothiazol-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 30h;49%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

6-chloro-4-({[(1S)-1,2,2-trimethylpropyl]amino}methyl)-2-pyridinamine
1365839-50-4

6-chloro-4-({[(1S)-1,2,2-trimethylpropyl]amino}methyl)-2-pyridinamine

N-[6-chloro-4-({[(1S)-1,2,2-trimethylpropyl]amino}methyl)-2-pyridinyl]-6-(methoxy)-1,3-benzothiazol-2-amine
1365839-43-5

N-[6-chloro-4-({[(1S)-1,2,2-trimethylpropyl]amino}methyl)-2-pyridinyl]-6-(methoxy)-1,3-benzothiazol-2-amine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h; Inert atmosphere;45%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

3-aminopyrazole
1820-80-0

3-aminopyrazole

1-(6-methoxybenzothiazol-2-yl)-1H-pyrazol-3-ylamine
1355241-13-2

1-(6-methoxybenzothiazol-2-yl)-1H-pyrazol-3-ylamine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 24h;44%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

6-chloro-4-(4-morpholinylmethyl)-2-pyridinamine
1334294-43-7

6-chloro-4-(4-morpholinylmethyl)-2-pyridinamine

N-[6-chloro-4-(4-morpholinylmethyl)-2-pyridinyl]-6-(methyloxy)-1,3-benzothiazol-2-amine
1365839-39-9

N-[6-chloro-4-(4-morpholinylmethyl)-2-pyridinyl]-6-(methyloxy)-1,3-benzothiazol-2-amine

Conditions
ConditionsYield
With sodium t-butanolate In tetrahydrofuran at 20 - 60℃; for 94h;44%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

diisopropyl ether-tetrahydrofuran

diisopropyl ether-tetrahydrofuran

2-cyano-6-hydroxybenzothiazole
939-69-5

2-cyano-6-hydroxybenzothiazole

Conditions
ConditionsYield
With trimethylsilyl iodide In diethyl ether; chloroform; dimethyl sulfoxide42%
propylamine
107-10-8

propylamine

2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

6-methoxy-N-propylbenzo[d]thiazol-2-amine

6-methoxy-N-propylbenzo[d]thiazol-2-amine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 70℃; for 15h;38%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-piperidinecarboxamide
924643-90-3

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-piperidinecarboxamide

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-1-[6-(methyloxy)-1,3-benzothiazol-2-yl]-3-piperidinecarboxamide
1340598-20-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-1-[6-(methyloxy)-1,3-benzothiazol-2-yl]-3-piperidinecarboxamide

Conditions
ConditionsYield
In (+/-)-2-pentanol; acetonitrile at 200℃; for 0.166667h; Microwave irradiation;35%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

(2-ethylsulfonylphenyl)-piperazin-1-yl-methanone

(2-ethylsulfonylphenyl)-piperazin-1-yl-methanone

(2-ethylsulfonylphenyl)-[4-(6-methoxy-1,3-benzothiazol-2-yl)piperazin-1-yl]methanone

(2-ethylsulfonylphenyl)-[4-(6-methoxy-1,3-benzothiazol-2-yl)piperazin-1-yl]methanone

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water for 15h; Reflux;35%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-(thiophen-2-ylsylfonyl)piperidine-4-carboxamide
1095340-42-3

N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-(thiophen-2-ylsylfonyl)piperidine-4-carboxamide

N-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide
1095340-75-2

N-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)-1-(thiophen-2-ylsulfonyl)piperidine-4-carboxamide

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran Suzuki coupling; Reflux;31%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl
14691-88-4

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl

4-(6'-methoxy-benzo[d]thiazol-2'-amino)-1-oxyl-2,2,6,6-tetramethyl-piperidine

4-(6'-methoxy-benzo[d]thiazol-2'-amino)-1-oxyl-2,2,6,6-tetramethyl-piperidine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 110℃; for 18h;24%
In N,N-dimethyl-formamide at 110℃; for 18h;24%
2-chloro-6-(methyloxy)-1,3-benzothiazole
2605-14-3

2-chloro-6-(methyloxy)-1,3-benzothiazole

N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine

N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine

N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N3-(6-methoxybenzo[d]thiazol-2-yl)propane-1,3-diamine hydrochloride

N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)-N3-(6-methoxybenzo[d]thiazol-2-yl)propane-1,3-diamine hydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloro-6-(methyloxy)-1,3-benzothiazole; N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 2h; Inert atmosphere;
Stage #2: With hydrogenchloride In methanol
20%

2605-14-3Relevant articles and documents

Preparation method of 2-chloro-6-methoxybenzothiazole

-

Paragraph 0028; 0029; 0030, (2019/03/28)

The invention discloses a preparation method of 2-chloro-6-methoxybenzothiazole, and belongs to the field of medical intermediates. The method comprises the following steps: dissolving 2-amino-6-methoxybenzothiazole in an organic solvent, adding a hydrochloric acid solution, dropwise adding a sodium nitrite solution, and after completion of the reaction, adding a hydrochloric acid solution containing a catalyst, cooling, and recrystallizing to obtain a target product. The preparation method disclosed by the invention is simple, the raw materials are easy to obtain, the reagents and drugs usedin an operation process are relatively low in toxicity, reaction conditions are mild, the time is short, the yield is high, the cost is low, three wastes are little, and the target product is high incontent and high in purity, and the suitability for industrial production is achieved.

TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

-

Paragraph 0326; 0327, (2018/03/25)

The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II):

Synthesis and antibacterial evaluation of a novel series of 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles

Stella, Alessandro,Segers, Kenneth,De Jonghe, Steven,Vanderhoydonck, Bart,Rozenski, Jef,Anne, Jozef,Herdewijn, Piet

experimental part, p. 253 - 265 (2011/09/30)

The 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazole scaffold was selected as a central core structure for the discovery of novel antibacterial compounds. A systematic variation of the substituents on the oxo-pyrazole moiety, as well as on the benzo moiety, led to the creation of a small and focused library of benzothiazoles that was subjected to antibacterial screening. In a first round of screening, activity of the compounds against six representative microorganisms was established. For the most potent congeners, MIC values against S. aureus and P. aeruginosa were determined. The structure-activity relationship study clearly revealed that subtle structural variations influence the antibacterial activity to a large extent. The most potent congeners displayed MIC values of 3.30 μM.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2605-14-3