1374855-82-9

Basic information

• Product Name: (E)-N-(2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide
• Synonyms: (E)-N-(2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide
• CAS NO: 1374855-82-9
• Molecular Weight: 496.532
• Mol File: 1374855-82-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-(2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide(1374855-82-9)
• EPA Substance Registry System: (E)-N-(2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl)-3-(4-(trifluoromethyl)phenyl)acrylamide(1374855-82-9)

Safety Data

• Hazardous Substances Data: 1374855-82-9(Hazardous Substances Data)

Upstream product

• 850172-44-0 2-chloro-4-methyl-6-nitroquinazoline 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 1374568-06-5 C₁₇H₂₂N₄O 
• 2062-26-2 3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid 
• 1374568-39-4 C₁₇H₂₀N₄O₃ 
• 850172-43-9 4-methyl-6-nitroquinazolin-2-ol 
• 69559-56-4 N-(2-acetylphenyl)-2,2,2-trichloroacetamide 
• 101466-85-7 ethyl (E)-4-trifluoromethylcinnamate 
• 551-93-9 2-aminoacetophenone 
• 34790-24-4 4-methylquinazolin-2-ol 

Relevant articles and documents

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2

Melanin concentrating hormone receptor 1 (MCHR1) antagonists have potential for the treatment of obesity and several CNS disorders. In the preceding article, we have described a novel series of quinazolines as MCHR1 antagonists and demonstrated in vivo proof of principle with an early lead. Herein we describe the detailed SAR and SPR studies to identify an optimized lead candidate having good efficacy in a sub-chronic DIO model with a good cardiovascular safety window.