1374856-34-4

Usage

Uses

Used in Pharmaceutical Synthesis:
(E)-ethyl 3-(4-(difluoromethoxy)phenyl)acrylate is used as a key building block in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, (E)-ethyl 3-(4-(difluoromethoxy)phenyl)acrylate serves as a starting material for the development of new pesticides and other agricultural chemicals. Its properties contribute to the effectiveness and safety of these products.
Used in Functional Material Development:
(E)-ethyl 3-(4-(difluoromethoxy)phenyl)acrylate is also utilized in the development of functional materials, which are materials designed to exhibit specific properties for particular applications, such as in electronics or energy storage.
Used in Polymer and Coating Production:
(E)-ethyl 3-(4-(difluoromethoxy)phenyl)acrylate is used as a starting material for the production of polymers and coatings, where its unique properties can enhance the performance and durability of the final products.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 73960-07-3 4-difluoromethoxybenzaldehyde 

Relevant academic research and scientific papers

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2

Melanin concentrating hormone receptor 1 (MCHR1) antagonists have potential for the treatment of obesity and several CNS disorders. In the preceding article, we have described a novel series of quinazolines as MCHR1 antagonists and demonstrated in vivo proof of principle with an early lead. Herein we describe the detailed SAR and SPR studies to identify an optimized lead candidate having good efficacy in a sub-chronic DIO model with a good cardiovascular safety window.

Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11 - 13 under acidic conditions afforded a series of dioxane-triazole compounds 14 - 16. The antifungal activities of the compounds 14 - 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond(s) and an aromatic ring substituted with an electron-withdrawing group in the side chain. Among the derivatives, R-102557 (16R: Ar=4-(2,2,3,3- tetrafluoropropoxy)phenyl) showed excellent in vivo activities against Candida, Aspergillus and Cryptococcus species. It also showed high tolerance in a preliminary toxicity study in rats.