1374864-77-3

Upstream product

• 937-00-8 3-trifluoromethyl-thiophenol 
• 1194-02-1 4-fluorobenzonitrile 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 36801-01-1 4-cyanobenzenethiol 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 1374862-64-2 2-(methylsulfonyl)-4-(trifluoromethyl)-N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)benzamide 
• 1374863-30-5 (R)-N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)pyrrolidine-2-carboxamide 
• 1374863-38-3 2-(1-aminocyclohexyl)-N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)acetamide 
• 1374864-79-5 (4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)methanamine 
• 1374864-78-4 4-((3-(trifluoromethyl)phenyl)sulfonyl)benzonitrile 
• 1374863-09-8 2-(trifluoromethyl)-6-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 
• 1374864-87-5 C₂₄H₂₇F₃N₂O₅S 
• 1374864-88-6 C₂₇H₃₃F₃N₂O₅S 

Relevant academic research and scientific papers

Room-Temperature Arylation of Thiols: Breakthrough with Aryl Chlorides

The formation of aryl C?S bonds is an important chemical transformation because aryl sulfides are valuable building blocks for the synthesis of biologically and pharmaceutically active molecules and organic materials. Aryl sulfides have traditionally been synthesized through the transition-metal-catalyzed cross-coupling of aryl halides with thiols. However, the aryl halides used are usually bromides and iodides; readily available, low-cost aryl chlorides often not reactive enough. Furthermore, the deactivation of transition-metal catalysts by thiols has forced chemists to use high catalyst loadings, specially designed ligands, high temperatures, and/or strong bases, thus leading to high costs and the incompatibility of some functional groups. Herein, we describe a simple and efficient visible-light photoredox arylation of thiols with aryl halides at room temperature. More importantly, various aryl chlorides are also effective arylation reagents under the present conditions.

Simple N-Heterocyclic Carbenes as Ligands in Ullmann-Type Ether and Thioether Formations

A simple N-heterocyclic carbene (NHC) derived from 1-methyl-3-ethylimidazolium tetrafluoroborate was found to be an efficient ligand for a range of copper-catalyzed cross-coupling reactions, leading to the formation of aromatic ethers and thioethers. (Figure presented.) .

BISARYLSULFONE AND DIALKYLARYLSULFONE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS

The invention relates to bisarylsulfone and dialkylarylsulfone compounds (e.g., compounds according to any of Formulas (I)-(IX) or compounds (1)-(227) of Tables 4 and 5) useful in treating conditions associated with calcium channel function, and particularly conditions associated with N-type calcium channel activity. The invention also relates to pharmaceutical compositions that include these bisarylsulfone compounds, as well methods for the treatment of conditions such as cardiovascular disease, epilepsy, cancer and pain.