1374868-77-5

Basic information

• Product Name: 4-bromo-1,3-dimethyl-1H-Pyrazole-5-methanol
• Synonyms: 4-bromo-1,3-dimethyl-1H-Pyrazole-5-methanol;(4-bromo-1,3-dimethyl-1H-pyrazol-5-yl)methanol
• CAS NO: 1374868-77-5
• Molecular Weight: 205.054
• Mol File: 1374868-77-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 4-bromo-1,3-dimethyl-1H-Pyrazole-5-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1,3-dimethyl-1H-Pyrazole-5-methanol(1374868-77-5)
• EPA Substance Registry System: 4-bromo-1,3-dimethyl-1H-Pyrazole-5-methanol(1374868-77-5)

Safety Data

• Hazardous Substances Data: 1374868-77-5(Hazardous Substances Data)

Upstream product

• 57012-20-1 (1,3-dimethyl-1H-pyrazol-5-yl)methanol 
• 5775-89-3 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid ethyl ester 
• 5744-40-1 ethyl 1,3-dimethylpyrazole-5-carboxylate 
• 5775-88-2 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid 

Downstream Products

• 1350323-55-5 (4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1,3-dimethyl-1H-pyrazol-5-yl)methanol 

Relevant articles and documents

MACROCYCLES AND THEIR USE

The present disclosure relates to macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer.

MACROCYCLIC CHLORINE SUBSTITUTED INDOLE DERIVATIVES

The present invention relates to macrocyclic indole derivatives of general formula (I) : (I), in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active 10 ingredients.

MACROCYCLIC FLUORINE SUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS, FOR USE IN THE TREATMENT OF CANCER

The present invention relates to macrocyclic indole derivatives of general formula (I) : in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.