5775-89-3

Usage

Uses

Used in Pharmaceutical Industry:
1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the creation of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid ethyl ester is utilized as a precursor in the development of agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications, such as pest control and crop protection.
Used in Organic Synthesis:
1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid ethyl ester is used as a versatile building block in organic synthesis. Its chemical properties allow it to be a crucial component in the formation of a wide range of organic compounds, contributing to the advancement of chemical research and development.
It is essential to handle 1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid ethyl ester with proper care, adhering to safety guidelines for its storage, transportation, and usage to ensure the safety of both individuals and the environment.

Upstream product

• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 
• 74-88-4 methyl iodide 
• 5744-40-1 ethyl 1,3-dimethylpyrazole-5-carboxylate 
• 615-79-2 ethyl 2,4-diketopentanoate 

Downstream Products

• 5775-88-2 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid 
• 119169-62-9 C₆H₆BrClN₂O 
• 1374868-77-5 (4-bromo-1,3-dimethyl-1H-pyrazol-5-yl)methanol 
• 1454848-24-8 ((4-bromo-5-cyano-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

MACROCYCLES AND THEIR USE

The present disclosure relates to macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer.

Synthesis method of glatianide intermediate

The invention provides a synthesis method of a strain facitinib intermediate, which takes acetone oxalate as a starting raw material in a simple and easy manner and is cyclized in sequence. The bromo, propionamide, bromination, amidation, deprotection and dehydration 7 steps give (4 - bromo -5 - cyano -1 - methyl - 1H - pyraz -3 -yl) methyl tert-butyl carbamate. The synthesis method of the Litinib intermediate disclosed by the invention has the characteristics of easily available raw materials, simple operation, low cost, short steps and high yield.

MACROCYCLIC CHLORINE SUBSTITUTED INDOLE DERIVATIVES

The present invention relates to macrocyclic indole derivatives of general formula (I) : (I), in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active 10 ingredients.

ARYL ANNULATED MACROCYCLIC INDOLE DERIVATIVES

The present invention relates to aryl annulated macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

MACROCYCLIC CHLORINE SUBSTITUTED INDOLE DERIVATIVES

The present invention relates to macrocyclic indole derivatives of general formula (I) : in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

MACROCYCLIC FLUORINE SUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS, FOR USE IN THE TREATMENT OF CANCER

The present invention relates to macrocyclic indole derivatives of general formula (I) : in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

MACROCYCLIC INDOLE DERIVATIVES

The present invention relates to macrocyclic indole derivatives of general formula (I) : (I), in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Synthesis and anti-TMV activity of novel N-(3-alkyl-1H-pyrazol-4-yl)-3- alkyl-4-substituted-1H-pyrazole-5-carboxamides

In order to investigate the biological activity of novel bis-pyrazole compounds, a series of N-(3-alkyl-5-(N-methylcarbamyl)-1H-pyrazol-4-yl)-3-alkyl- 4-substituted-1H-pyrazole-5-carboxamides were designed and synthesized with ethyl 3-alkyl-1H-pyrazole-5-