1374869-97-2

Upstream product

• 1612-65-3 2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 4302-52-7 4-ethynylveratrole 
• 2316-26-9 3,4-dimethoxycinnamic acid 
• 69731-27-7 1-bromo-2-(3',4'-dimethoxyphenyl)ethene 
• 97243-37-3 3-(3',4'-dimethoxyphenyl)-2,3-dibromopropanoic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 1374869-94-9 1-(3,4-dimethoxyphenylethyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

C-1 alkynylation of N-methyltetrahydroisoquinolines through CDC: A direct access to phenethylisoquinoline alkaloids

Direct cross-coupling between N-methyltetrahydroisoquinolines and alkynes using CuI-DEAD is presented. It affords the regioselective C-1-alkynylated products in good yield. This regio-selectivity is in contrast to the results reported earlier in the reaction of N,N-dimethylbenzyl amine where the N-methyl alkynylated product was formed exclusively or predominantly. The C-1-substituted propargylic isoquinolines were easily reduced to phenethylisoquinolines with Pd/C. This reaction sequence provides a short route to synthesize methopholine, homolaudanosine and other phenethylisoquinoline alkaloids. Georg Thieme Verlag Stuttgart · New York.