97243-37-3

Upstream product

• 2316-26-9 3,4-dimethoxycinnamic acid 
• 121-33-5 vanillin 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 69731-27-7 1-bromo-2-(3',4'-dimethoxyphenyl)ethene 
• 2316-26-9 3,4-dimethoxycinnamic acid 
• 176177-42-7 1-bromo-2-(3,4-dimethoxyphenyl)ethylene 
• 1374869-97-2 1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1374870-00-4 6,7-dimethoxy-1-(3,4-dimethoxyphenylethynyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1374869-94-9 1-(3,4-dimethoxyphenylethyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 32487-03-9 6,7-dimethoxy-1-(3,4-dimethoxyphenylethyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 4302-52-7 4-ethynylveratrole 

Relevant academic research and scientific papers

C-1 alkynylation of N-methyltetrahydroisoquinolines through CDC: A direct access to phenethylisoquinoline alkaloids

Direct cross-coupling between N-methyltetrahydroisoquinolines and alkynes using CuI-DEAD is presented. It affords the regioselective C-1-alkynylated products in good yield. This regio-selectivity is in contrast to the results reported earlier in the reaction of N,N-dimethylbenzyl amine where the N-methyl alkynylated product was formed exclusively or predominantly. The C-1-substituted propargylic isoquinolines were easily reduced to phenethylisoquinolines with Pd/C. This reaction sequence provides a short route to synthesize methopholine, homolaudanosine and other phenethylisoquinoline alkaloids. Georg Thieme Verlag Stuttgart · New York.

ISOLATION OF HYPOXOSIDE FROM HYPOXIS ROOPERI AND SYNTHESIS OF (E)-1,5-BIS(3',4'-DIMETHOXYPHENYL)PENT-4-EN-1-YNE

Isolation of the known diglucoside of (E)-1,5-bis(3',4'-dihydroxyphenyl)pent-4-en-1-yne (hypoxoside) from Hypoxis rooperi is described.In vivo tests indicate low toxic properties.A general synthesis for the introduction of the pentenyne link between two aromatic rings is described.Key words: Hypoxis rooperi; Hypoxidaceae; corms; hypoxoside; 1,5-diphenylpent-4-en-1-yne; rooperol; synthesis.