1374870-01-5

Upstream product

• 120494-01-1 6-isopropoxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 768-60-5 4-methoxyphenylacetylen 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 31448-61-0 2,3-dibromo-3-(4-methoxy-phenyl)-propionic acid 
• 27570-08-7 4-(2-bromo-vinyl)-anisole 

Downstream Products

• 1374869-92-7 7-methoxy-1-(4-methoxyphenylethyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol 

Relevant academic research and scientific papers

C-1 alkynylation of N-methyltetrahydroisoquinolines through CDC: A direct access to phenethylisoquinoline alkaloids

Direct cross-coupling between N-methyltetrahydroisoquinolines and alkynes using CuI-DEAD is presented. It affords the regioselective C-1-alkynylated products in good yield. This regio-selectivity is in contrast to the results reported earlier in the reaction of N,N-dimethylbenzyl amine where the N-methyl alkynylated product was formed exclusively or predominantly. The C-1-substituted propargylic isoquinolines were easily reduced to phenethylisoquinolines with Pd/C. This reaction sequence provides a short route to synthesize methopholine, homolaudanosine and other phenethylisoquinoline alkaloids. Georg Thieme Verlag Stuttgart · New York.