1374878-21-3Relevant articles and documents
Chiral guanidine-catalyzed asymmetric direct vinylogous Michael reaction of α,β-unsaturated γ-butyrolactams with alkylidene malonates
Yang, Yang,Dong, Shunxi,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming
supporting information; experimental part, p. 5040 - 5042 (2012/06/01)
The asymmetric direct vinylogous Michael reaction of α,β- unsaturated γ-butyrolactams with alkylidene malonates has been developed. Various 5-substituted 3-pyrrolidin-2-ones were obtained in high yields (up to 93%) with excellent stereoselectivities (up to 94% ee, 95:5 dr), using a novel bifunctional C1-symmetric guanidine organocatalyst embodied a secondary amine subunit. The Royal Society of Chemistry 2012.