1374880-20-2Relevant academic research and scientific papers
Organocatalytic Enantioselective Transfer Hydrogenation of β-Amino Nitroolefins
Ferraro, Antonino,Bernardi, Luca,Fochi, Mariafrancesca
, p. 1561 - 1565 (2016)
The asymmetric organocatalytic transfer hydrogenation of β-acylamino and β-tert-butyloxycarbonylamino nitroolefins has been successfully realised in excellent enantioselectivities and yields (up to >99% ee, 97% yield) with a simple thiourea catalyst and a Hantzsch ester as hydrogen source, giving a direct access to enantiomerically pure β-amino nitroalkanes. (Figure presented.).
Biodegradable Chitosan-Derived Thioureas as Recoverable Supported Organocatalysts – Application to the Stereoselective Aza-Henry Reaction
Andrés, José M.,González, Fernando,Maestro, Alicia,Pedrosa, Rafael,Valle, María
, p. 3658 - 3665 (2017/07/22)
Eight different biodegradable chitosan-supported bifunctional chiral thioureas have been prepared as a greener and more sustainable alternative to those supported on petrochemical-derived polymers. These organocatalysts promoted an enantioselective aza-He
A new family of cinchona-derived bifunctional asymmetric phase-transfer catalysts: Application to the enantio- and diastereoselective nitro-Mannich reaction of amidosulfones
Johnson, Kayli M.,Rattley, Matt S.,Sladojevich, Filippo,Barber, David M.,Nunez, Marta G.,Goldys, Anna M.,Dixon, Darren J.
, p. 2492 - 2495 (2012/08/28)
A new family of bifunctional H-bond donor phase-transfer catalysts derived from cinchona alkaloids has been developed and evaluated in the enantio- and diastereoselective nitro-Mannich reaction of in situ generated N-Boc-protected imines of aliphatic, aromatic, and heteroaromatic aldehydes. Under optimal conditions, good reactivity and high diastereoselectivities (up to 24:1 dr) and enantioselectivities (up to 95% ee) were obtained using a 9-amino-9- deoxyepiquinidine-derived phase-transfer catalyst possessing a 3,5-bis(trifluoromethyl)phenylurea H-bond donor group at the 9-position.
