1374893-41-0

Upstream product

• 858669-65-5 (2S,3S)-3-(4-Methoxy-benzylsulfanyl)-2-(4-nitro-benzenesulfonylamino)-butyric acid allyl ester 
• 858669-62-2 N-p-nitrophenylsulfonyl-D-threonine allyl ester 
• 858669-63-3 (2R,3R)-1-(p-nitrophenylsulfonyl)-3-methyl-2-azidirinecarboxyic acid allyl ester 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 1330632-52-4 (5R,8S,9S)-1-(9H-fluoren-9-yl)-8-methyl-9-((4-nitrobenzyloxy)carbonyl)-13-(4-nitrophenyl)-3,11-dioxo-2,12-dioxa-7-thia-4,10-diazatridecane-5-carboxylic acid 
• 1374893-30-7 C₂₇H₂₇N₃O₉S 
• 1374893-42-1 C₁₉H₁₉N₃O₈S 
• 1374893-31-8 C₄₁H₄₂N₄O₁₂S 

Relevant academic research and scientific papers

Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry

Lantibiotics are a family of antibacterial peptide natural products characterized by the post-translational installation of the thioether-containing amino acids lanthionine and methyllanthionine. Until recently, only a single naturally occurring stereoche

Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X

Lantibiotics are a large family of antibacterial peptide natural products containing multiple post-translational modifications, including the thioether structures lanthionine and methyllanthionine. Efforts to probe structure-activity relationships and engineer improved pharmacological properties have driven the development of new methods to produce non-natural analogues of these compounds. In this study, solid-supported chemical synthesis was used to produce analogues of the potent lantibiotic epilancin 15X, in order to assess the importance of several N-terminal post-translational modifications for biological activity. Surprisingly, substitution of these moieties, including the unusual N-terminal d-lactyl moiety, resulted in relatively small changes in the antimicrobial activity and pore-forming ability of the peptides.