1330632-52-4Relevant academic research and scientific papers
Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry
Knerr, Patrick J.,Van Der Donk, Wilfred A.
supporting information, p. 7094 - 7097 (2013/06/27)
Lantibiotics are a family of antibacterial peptide natural products characterized by the post-translational installation of the thioether-containing amino acids lanthionine and methyllanthionine. Until recently, only a single naturally occurring stereoche
Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X
Knerr, Patrick J.,Van Der Donk, Wilfred A.
, p. 7648 - 7651 (2012/06/18)
Lantibiotics are a large family of antibacterial peptide natural products containing multiple post-translational modifications, including the thioether structures lanthionine and methyllanthionine. Efforts to probe structure-activity relationships and engineer improved pharmacological properties have driven the development of new methods to produce non-natural analogues of these compounds. In this study, solid-supported chemical synthesis was used to produce analogues of the potent lantibiotic epilancin 15X, in order to assess the importance of several N-terminal post-translational modifications for biological activity. Surprisingly, substitution of these moieties, including the unusual N-terminal d-lactyl moiety, resulted in relatively small changes in the antimicrobial activity and pore-forming ability of the peptides.
Solid supported chemical syntheses of both components of the lantibiotic lacticin 3147
Liu, Wei,Chan, Alice S. H.,Liu, Hongqiang,Cochrane, Stephen A.,Vederas, John C.
, p. 14216 - 14219 (2011/11/05)
Lantibiotics are antimicrobial peptides produced by bacteria. Some are employed for food preservation, whereas others have therapeutic potential due to their activity against organisms resistant to current antibiotics. They are ribosomally synthesized and
