137490-86-9Relevant articles and documents
Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic α-Amino Acids
Amer, Mostafa M.,Carrasco, Ana C.,Leonard, Daniel J.,Ward, John W.,Clayden, Jonathan
supporting information, p. 7977 - 7981 (2019/01/04)
Imidazolidinone derivatives of a range of aromatic α-amino acids, on treatment with phosgene and potassium iodide, undergo a mild Bischler-Napieralski-style cyclocarbonylation reaction that generates a tricyclic lactam by insertion of a C=O group between amino acid nitrogen and the ortho position of the aryl substituent. Regio- and diastereoselective functionalization of the lactam generates a library of substituted dihydroisoquinolinones and their congeners in enantioenriched form.
New renin-inhibitory peptides and their use
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, (2008/06/13)
Compounds of formulaR 1 CO--NH--CH(R 2)--CONH--CH(R 3)--X[wherein:R 1 represents alkyl having an α-amino or protected α-amino substituent and an aryl, heterocyclic or heterocyclic-dithio substituent;R 2 represents a variety of aliphatic and cycloaliphatic