1374969-99-9

Basic information

• Product Name: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-(3-methylanilino)pyridine-3-carboxamide
• Synonyms: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-(3-methylanilino)pyridine-3-carboxamide
• CAS NO: 1374969-99-9
• Molecular Weight: 364.45
• Mol File: 1374969-99-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-(3-methylanilino)pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-(3-methylanilino)pyridine-3-carboxamide(1374969-99-9)
• EPA Substance Registry System: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-(3-methylanilino)pyridine-3-carboxamide(1374969-99-9)

Safety Data

• Hazardous Substances Data: 1374969-99-9(Hazardous Substances Data)

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 919354-52-2 ethyl 2,6-dichloro-5-cyanopyridine-3-carboxylate 

Relevant articles and documents

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity

To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound 1, which has a pyridine moiety, was found. Referring to their X-ray crystal structure with FES proto-oncogene tyrosine kinase, as a surrogate of FER followed by chemical modification including scaffold hopping of the pyridine template, we discovered pyrido-pyridazinone derivatives with potent FER kinase inhibitory activity. Here, we disclose the structure-activity relationship on the scaffold and representative compound 21 (DS21360717), which showed in vivo antitumor efficacy in a subcutaneous tumor model.