1374977-60-2Relevant academic research and scientific papers
Active conformation of seven-membered-ring benzolactams as new ACAT inhibitors: Latent chirality at N5 in the 1,5-benzodiazepin-2-one nucleus
Tabata, Hidetsugu,Wada, Naoya,Takada, Yuko,Nakagomi, Jun,Miike, Tomohiro,Shirahase, Hiroaki,Oshitari, Tetsuta,Takahashi, Hideyo,Natsugari, Hideaki
, p. 1572 - 1576 (2012/04/10)
Nitrogen chirality: Potent new ACAT inhibitors with seven-membered-ring benzolactams as the core structures were first prepared, and the axial chirality recognized by the enzyme was clarified (e.g., 1; see scheme). The chirality at the axis (aS) of 1 controls the conformation of the entire lactam ring, causing the N5-CH3 to arrange in a pseudo-equatorial position (i.e., the amine at N5 is a chiral center with the S-configuration) both in the crystal state and in solution. Copyright
