1374994-81-6 Usage
Uses
Used in Bioconjugation for Biological Research:
(2,2′-(7-(4-isothiocyanatobenzyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) is used as a chelating agent for bioconjugation in biological research, enabling the attachment of proteins and other biomolecules to fluorescent dyes, drugs, or solid supports. This facilitates various applications such as the development of biosensors, immunoassays, and the study of molecular interactions.
Used in Bioconjugation for Diagnostics:
In the diagnostics industry, (2,2′-(7-(4-isothiocyanatobenzyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) is used as a chelating agent for the creation of diagnostic tools. Its ability to bind with metal ions and biomolecules makes it suitable for the development of imaging agents and probes that can be used to detect and monitor diseases.
Used in Drug Delivery Systems:
(2,2′-(7-(4-isothiocyanatobenzyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) is utilized as a component in drug delivery systems, where its chelating properties and ability to bind with biomolecules can enhance the targeting and delivery of therapeutic agents to specific cells or tissues, improving the efficacy and reducing the side effects of treatments.
Used in Biotechnological Applications:
In the biotechnology field, (2,2′-(7-(4-isothiocyanatobenzyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) is employed as a key component in the development of bioconjugates. These conjugates have potential uses in various applications, such as the creation of biosensors for environmental monitoring, the development of affinity reagents for protein purification, and the engineering of novel biomaterials for tissue engineering and regenerative medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 1374994-81-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,4,9,9 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1374994-81:
(9*1)+(8*3)+(7*7)+(6*4)+(5*9)+(4*9)+(3*4)+(2*8)+(1*1)=216
216 % 10 = 6
So 1374994-81-6 is a valid CAS Registry Number.
1374994-81-6Relevant articles and documents
TRIAZANONANE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR ENHANCED FLUORINE-18 LABELING
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, (2013/12/04)
The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the present invention forms a complex with a metal-fluoride and displays an effect of increasing the labeling efficiency up to 78-90% when labeling F-18, thus enabling use in various radioactive medicine labeling (In the chemical formula 1, R1, R2, A. E. X, n and m are as defined in the present description.)
Development of a bifunctional chelating agent containing isothiocyanate residue for one step F-18 labeling of peptides and application for RGD labeling
Shetty, Dinesh,Jeong, Jae Min,Kim, Young Ju,Lee, Ji Youn,Hoigebazar, Lathika,Lee, Yun-Sang,Lee, Dong Soo,Chung, June-Key
, p. 5941 - 5947 (2012/11/06)
We report herein a novel isothiocyanate active ligand for fluorine-18 labeling prepared by four step synthesis. It can be conjugated to a target molecule containing an amino functional group under weak basic conditions by way of thiourea bond formation. We explored the application of synthesized ligand by conjugating to well known αvβ3 integrin targeting peptide, c(RGDyK). The conjugated peptide showed good radiochemical yield and efficiency with an excellent radiochemical purity (97.1 ± 1.2%) in a short reaction time (10 min). Labeled peptide showed excellent in vitro and in vivo stability (>95%). αvβ3 integrin specific tumor uptake was observed both in biodistribution and small animal microPET studies on αvβ3-positive U87MG (human glioma cells) xenograft bearing mice. In general, successful application of synthesized ligand for labeling of RGD peptide could facilitate the possibility of using this ligand for labeling peptides containing an amino functional group.
