1374997-70-2Relevant academic research and scientific papers
A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid
Kaiser, Martin Maxmilian,Jansa, Petr,Dra?ínsky, Martin,Janeba, Zlatko
, p. 4003 - 4012 (2012/07/28)
A convenient and efficient synthesis of a novel class of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid has been developed. The key step of the synthesis is the optimized oxidation of the 3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) analogues to the corresponding 2′-carboxy-PME (CPME) derivatives using the TEMPO/NaClO2/NaClO oxidizing system. Although (S)-3-(adenin-9-yl)-2-(phosphonomethoxy)propanoic acid ((S)-CPMEA) has been designed as a compound with potential anti-HIV activity, none of the newly prepared CPME analogues exhibited any antiviral activity.
