137506-94-6Relevant articles and documents
Synthesis and anti-inflammatory activity of (3,5-di-tert-butyl-4-hydroxybenzylidene) cyclanones and related compounds
Varache-Beranger,Nuhrich,Amiell,Dufour,Devaux
, p. 551 - 556 (1991)
Some (3,5-di-tert-butyl-4-hydroxybenzylidene) cyclanones were synthesized and evaluated for anti-inflammatory activity in carragenin-induced rat paw edema assay. These compounds are slightly less active than phenylbutazone. Their inhibitory effects in vit
Synthesis of enantioenriched 4-thiazolidinone (-)-LY213829 by chemoselective benzylamide cleavage in the presence of a C-S bond
Hansen, Marvin M.,Harkness, Allen R.,Khau, Vien V.,Martinelli, Michael J.,Deeter, Jack B.
, p. 2515 - 2518 (2007/10/03)
(R)-2-Methylbenzylamine has been used to covalently 'resolve' thiol acid 7 and assemble 4-thiazolidinone 8a in one step. Selective deprotection of the 2-methylbenzylamide using lithium in ammonia/THF has been achieved in the presence of a readily hydrogen
Pyridine derivatives, their production and use
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, (2008/06/13)
There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine derivative of the formula (I): STR1 wherein R is an optionally substituted pyridine ring, X is a oxygen atom or --S(O)n--, wherein n is 0, 1 or 2, A is a bivalent C1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen or sulfur atom, R3 is a hydrogen atom or an optionally substituted hydrocarbon residue, R4 is an optionally substituted hydrocarbon residue or an optionally substituted monocyclic or bicyclic heterocyclic group, R3 and R4 may be joined together with the carbamoyl group or the thiocarbamoyl group to which they are attached to form an optionally substituted heterocyclic group, or R3 or R4 may be independently attached to A to form a ring, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier or diluent.