107902-68-1

Upstream product

• 1620-98-0 3,5-di-t-butyl-4-hydroxybenzaldehyde 
• 1055977-69-9 5-[(3,5-bis (1,1-dimethylethyl)-4-hydroxyphenyl)methylene]-2-thioxo-4-thiazolidinone 
• 1149-23-1 diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 137506-94-6 (Z)-5-(3,5-di-tert-butyl-4-hydroxyphenylmethylene)-4-oxo-2-thiazolidinethione 

Downstream Products

• 107902-67-0 tazofelone 
• 107902-67-0 (+)-5-<<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl>methyl>-4-thiazolidinone 
• 107902-67-0 (-)-5-<<3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl>methyl>-4-thiazolidinone 
• 179894-26-9 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-mercaptopropanoic acid 
• 188532-21-0 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-mercapto-propionamide 
• 17356-08-0 thiourea 
• 136433-34-6 Tazofelone sulfoxide 
• 183183-39-3 (S)-5-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-3-((R)-1-phenyl-ethyl)-thiazolidin-4-one 
• 188532-24-3 3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-hydroxymethylsulfanyl-propionamide 
• 107902-69-2 4-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-[1,3]oxathiolan-5-one 

Relevant academic research and scientific papers

Regiospecific reduction of 5-benzylidene-2,4-thiazolidinediones and 4- oxo-2-thiazolidinethiones using lithium borohydride in pyridine and tetrahydrofuran

The novel regiospecific and general reduction of 5-benzylidene-2,4- thiazolidinediones and 5-benzylidene-4-oxo-2-thiazolidinethiones to the corresponding 5-benzyl derivatives has been accomplished using lithium borohydride in pyridine and tetrahydrofuran. Sodium borohydride and lithium chloride can also be used under these conditions, which represents a cheaper alternative to lithium borohydride. (C) 2000 Elsevier Science Ltd.

Method for treating multiple sclerosis

Provided is a method of treating multiple sclerosis employing certain aryl-substituted rhodanines.

Synthesis of enantioenriched 4-thiazolidinone (-)-LY213829 by chemoselective benzylamide cleavage in the presence of a C-S bond

(R)-2-Methylbenzylamine has been used to covalently 'resolve' thiol acid 7 and assemble 4-thiazolidinone 8a in one step. Selective deprotection of the 2-methylbenzylamide using lithium in ammonia/THF has been achieved in the presence of a readily hydrogen

Aryl-substituted rhodanine derivatives

Provided are certain aryl-substituted rhodanine derivatives, treatment methods and pharmaceutical formulations thereof.

Method of treating inflammatory bowel disease

Provided is a method of treating inflammatory bowel disease in mammals utilizing certain benzyl-substituted rhodanine derivatives. Also provided are novel benzyl-substituted rhodanine derivatives and pharmaceutical compositions thereof, as well as a novel process for selectively isolating in substantially pure enantiomeric form the enantiomers of certain racemic benzyl-substituted rhodanine derivatives.

Method of treating type I diabetes

Provided is a method for treating Type I diabetes in mammals utilizing certain aryl-substituted rhodanine derivatives.