1375085-37-2

Basic information

• Product Name: C₁₇H₁₈N₂OS
• Synonyms: C₁₇H₁₈N₂OS
• CAS NO: 1375085-37-2
• Molecular Weight: 298.409
• Mol File: 1375085-37-2.mol

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₈N₂OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₈N₂OS(1375085-37-2)
• EPA Substance Registry System: C₁₇H₁₈N₂OS(1375085-37-2)

Safety Data

• Hazardous Substances Data: 1375085-37-2(Hazardous Substances Data)

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 6265-55-0 2-(4-hydroxyphenyl)benzothiazole 
• 1375085-29-2 C₂₅H₂₀N₂O₃S 

Relevant articles and documents

Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids

A series of berberine-phenyl-benzoheterocyclic (26-29) and tacrine-phenyl-benzoheterocyclic hybrids (44-46) were synthesised and evaluated as multifunctional anti-Alzheimer's disease agents. Compound 44b, tacrine linked with phenyl-benzothiazole by 3-carbon spacers, was the most potent AChE inhibitor with an IC50 value of 0.017 μM. This compound demonstrated similar Aβ aggregation inhibitory activity with cucurmin (51.8% vs 52.1% at 20 μM, respectively), indicating that this hybrid is an excellent multifunctional drug candidate for AD.