6265-55-0

Usage

Uses

Used in Chemical Sensing:
4-(2-benzothiazolyl)-pheno is used as a fluorescent probe for detecting metal ions, particularly due to its sensitivity and selectivity in chemical sensing applications.
Used in Biological Monitoring:
In the biological field, 4-(2-benzothiazolyl)-pheno serves as a tool for monitoring and detecting the presence of specific biologically relevant metal ions, contributing to research in areas such as biochemistry and molecular biology.
Used in Environmental Monitoring:
4-(2-benzothiazolyl)-pheno is utilized as an environmental sensor, helping to detect and measure metal ion concentrations in various environmental samples, which is crucial for assessing pollution levels and environmental health.
Used in Photodynamic Therapy:
In the medical field, specifically oncology, 4-(2-benzothiazolyl)-pheno is investigated for its potential as a photosensitizer in photodynamic therapy. This application takes advantage of its ability to generate reactive oxygen species upon light activation, which can be used to target and destroy cancer cells.
Used in Research and Development:
4-(2-benzothiazolyl)-pheno is employed in scientific research and development for the creation of new materials and technologies that leverage its unique fluorescent and chemical properties, further expanding its applications across various industries.

InChI:InChI=1/C13H9NOS/c15-10-7-5-9(6-8-10)13-14-11-3-1-2-4-12(11)16-13/h1-8,14H

Upstream product

• 98370-54-8 zinc 2-aminobenzenethiolate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 6265-92-5 2-(4-methoxy-phenyl)-benzothiazole 
• 1040034-32-9 C₁₃H₁₀INO₂ 
• 1141-88-4 2-Aminophenyl disulfide 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 95-16-9 1,3-Benzothiazole 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 108-95-2 phenol 
• 402-45-9 4-hydroxybenzotrifluoride 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 111218-97-4 4-(2-benzothiazolyl)phenyl laurate 
• 111243-65-3 4-(benzo[d]thiazol-2-yl)phenyl acetate 
• 117239-45-9 Ethyl p-(2-benzothiazolyl)phenoxyacetate 
• 111218-98-5 4-(2-benzothiazolyl)phenyl myristate 
• 84396-09-8 2-benzothiazole 
• 485842-97-5 4-(benzothiazol-2-yl)-4-hydroxy-2,5-cyclohexadienone 
• 120332-28-7 diethyl {2-[4-(benzothiazol-2-yl)phenoxy]ethyl}phosphonate 
• 84396-10-1 2-benzothiazole 
• 117239-46-0 p-(2-Benzothiazolyl)phenoxyacetylhydrazine 
• 117239-47-1 N-(2-Hydroxybenzylidene)-p-(2-benzothiazolyl)phenoxyacetylhydrazine 
• 134-81-6 benzil 
• 107334-30-5 2-{4-[[5-(3-Methyl-5-isoxazolyl)pentyl]oxy]phenyl}-benzothiazole 
• 1049018-49-6 C₃₄H₃₉N₃O₆S₃ 
• 1049018-53-2 (2S)-N-{4-(N-[4-(1,3-benzothiazol-2-yl)phenoxy]pentyl)oxy-5-methoxy-2-nitrobenzoyl}-pyrrolidine-2-carboxaldehyde diethylthioacetal 

Relevant academic research and scientific papers

Red and blue emitting fluorescent probe for cyanide and hypochlorite ions: Biological sensing and environmental analysis

Excessive levels of hypochlorite and cyanide ions are considered as the major threats towards human health and environment. Therefore, many researchers make considerable effort to develop small molecules for the quick, accurate and easy detection of biolo

A benzothiazole-based fluorescent probe for selective detection of H2S in living cells and mouse hippocampal tissues

This study reports a benzothiazole-based fluorescent probe EPS-HS for real-time detection of H2S. The probe is characterized in a large red-shift, good selectivity, high sensitivity and favorable biocompatibility. We measured the detection limi

Synthesis and antibacterial activity of hydroxylated 2-arylbenzothiazole derivatives

N-acyliminium reagents formed in situ from benzothiazole and alkyl chloroformates react with hydroxyarenes in a Friedel-Crafts manner, providing access to 2-(hydroxyaryl)-benzothiazolines with antibacterial properties.

A simple and sensitive fluorescent sensor platform for Al3+sensing in aqueous media and monitoring through combined PET and ESIPT mechanisms: Practical applications in drinking water and bio-imaging

In this study, a novel hydrazide-based compound, (E)-N′-(5-(benzo[d]thiazol-2-yl)-2-hydroxybenzylidene)furan-2-carbohydrazide (probe BOTH) was designed, characterized and prepared as a fluorogenic "turn-on"sensor for monitoring Al3+ in near-perfect aqueou

An efficient rapid synthesis of benzoxazoles and benzothiazoles using pma.Sio2 at room temperature under heterogeneous conditions

Treatment of 2-aminophenol (or 2-aminothiophenol) with aromatic aldehydes in the presence of phosphomolybdic acid on silica at room temperature affords the corresponding benzoxazoles (or benzothiazoles) in excellent yields (88-96%) under heterogeneous conditions. Benzoxazoles and benzothiazoles are formed in less than 10 min.

Ruthenium silicate (RS-1) zeolite: novel heterogeneous efficient catalyst for synthesis of 2-arylbenzothiazole derivatives

Abstract: Mesoporous silicate and transition metal (Ru+3) containing mesoporous silicate materials or ruthenium silicate Ru+3/Si+4 where synthesis by using hydrothermal process. Mesoporous ruthenium silicate (RS-1) and zeo

Ionic liquid-immobilized hybrid nanomaterial: an efficient catalyst in the synthesis of benzimidazoles and benzothiazoles via anomeric-based oxidation

Abstract: In this study, a novel ionic liquid immobilized on silica-coated cobalt-ferrite magnetic nanoparticles. This novel hybrid nanostructure (CoFe2O4@SiO2@PAF-IL) was characterized by various microscopic and spectroscopic techniques including Fourier transformation infrared spectroscopy (FT–IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (SEM), the electron-dispersive X-ray spectroscopy (EDS), vibrating sample magnetometer (VSM), and thermogravimetric analysis (TGA/DTG). The catalytic activity of prepared nanomaterial was considered in the synthesis of the benzothiazole and benzimidazole derivatives. This method has several advantages such as good to excellent yields, short reaction times, solvent-free and environmentally-benign conditions, and simple work-up. Besides, nanocatalyst can be easily separated from the reaction mixture with the external magnetic field and reused several times without any loss of its catalytic activity. Graphic abstract: [Figure not available: see fulltext.].

Pentafluorophenylammonium Triflate: A Mild, Efficient and Reusable Catalyst for the Synthesis of 2-Arylbenzothiazole and 2-Arylbenzothiazoline Derivatives in a Green Chemical Approach

In this work, one pot, simple and environmentally benign effective synthesis of 2-substituted benzothiazole and benzothiazoline derivatives are described in presence of PFPAT (pentafluorophenylammonium triflate) catalyst in water successfully. A series of benzothiazole derivative were synthesized by the reaction between 2-aminothiophenol and various aldehydes in good yields. Recyclability of the catalyst is observed for four times without loss of its activity in aqueous medium.

2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.

Preparation method of 2-aryl benzothiazole compound

The invention discloses a preparation method of a 2-arylbenzothiazole compound, which comprises the following steps: adding a reaction substrate 2-aminothiophenol and ketonic acid(or aldehyde) into adeep eutectic solvent, magnetically stirring in an oil bath pot at 60-90 DEG C, and carrying out after-treatment after the reaction is finished to obtain the 2-arylbenzothiazole compound, wherein a deep eutectic solvent is a reaction solvent, and other catalysts are not needed. The method is simple to operate, mild in reaction condition, efficient in reaction, high in atom economy, few in byproducts and green and environment-friendly in reaction process, and has popularization and application values.