1375150-73-4

Upstream product

• 1254831-47-4 (1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester 
• 199296-40-7 2-(tert-butyloxycarbonyl)-aminopyridine-5-carboxaldehyde 
• 1437501-99-9 (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt 
• 1254831-48-5 3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester 
• 1254831-46-3 (E)-2-(1-cyclohexyl-1H-imidazol-4-yl)-3-hydroxy-but-2-enedioic acid diethyl ester 
• 1437501-98-8 (R)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester 
• 1375150-71-2 (E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid 
• 1254831-53-2 (1-cyclohexyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-acetic acid ethyl ester 
• 1254831-51-0 4-cyclohexylamino-3-oxobutyric acid ethyl ester hydrochloride 

Downstream Products

• 1438404-18-2 (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid sodium salt 

Relevant academic research and scientific papers

Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives

The present invention relates to a process for the preparation of a compound of the formula I, which comprises reacting a compound of the formula IV with the compound of formula VII R15-A2-CHO and to novel intermediate compounds used therein.

CRYSTALLINE SALTS OF R)-3-[6-AMINO-PYRIDIN-3-YL]-2-(1-CYCLOHEXYL-1H-IMIDAZOL-4-YL)-PROPIONIC ACID

The invention relates to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1 -cyclohexyl- 1 H-imidazol-4-yl)-propionic acid which is in a crystalline form or in at least partially crystalline form as a monohydrate or anhydrate, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor).

SODIUM SALT OF (R)-3-[6-AMINO-PYRIDIN-3-YL]-2-(1-CYCLOHEXYL-1H-IMIDAZOL-4-YL)-PROPIONIC ACID

The invention relates to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid, and to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid which is in a crystalline form or in at least partially crystalline form, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor).

Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives

Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives The present invention relates to a process for the preparation of a compound of the formula (I), which comprises reacting a compound of the formula IV, (IV) with the compound of formula VII R15-A2-CHO and to novel intermediate compounds used therein.