199296-40-7

Basic information

• Product Name: TERT-BUTYL (5-FORMYLPYRIDIN-2-YL)CARBAMATE
• Synonyms: 2-(tert-ButoxycarbonylaMino)-5-pyridinecarboxaldehyde;6-Aminonicotinaldehyde, 6-BOC protected;6-Aminopyridine-3-carboxaldehyde, 6-BOC protected, tert-Butyl (5-formylpyridin-2-yl)carbamate, 2-[(tert-Butoxycarbonyl)amino]-5-formylpyridine;2-Boc-AMinopyridine-5-aldehyde;tert-butyl N-(5-formylpyridin-2-yl)carbamate;2-(tert-Butoxycarbonylamino)pyridine-5-carboxaldehyde;(5-Formylpyridine-2-yl)-carbamic acid tert butyl ester;Carbamicacid, N-(5-formyl-2-pyridinyl)-, 1,1-dimethylethyl ester
• CAS NO: 199296-40-7
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.24
• Product Categories: Building Blocks;Pyridine
• Mol File: 199296-40-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 316.297 °C at 760 mmHg
• Flash Point: 145.092 °C
• Appearance: /
• Density: 1.212 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.08±0.70(Predicted)
• Water Solubility: Soluble in water.
• Sensitive: Air & Light Sensitive
• CAS DataBase Reference: TERT-BUTYL (5-FORMYLPYRIDIN-2-YL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL (5-FORMYLPYRIDIN-2-YL)CARBAMATE(199296-40-7)
• EPA Substance Registry System: TERT-BUTYL (5-FORMYLPYRIDIN-2-YL)CARBAMATE(199296-40-7)

Safety Data

• Hazardous Substances Data: 199296-40-7(Hazardous Substances Data)

Usage

Uses

2-(Boc-amino)pyridine-5-carboxaldehyde is used as active pharmaceutical ingredient or intermediates, fine chemicals.

InChI:InChI=1/C11H14N2O3/c1-11(2,3)16-10(15)13-9-5-4-8(7-14)6-12-9/h4-7H,1-3H3,(H,12,13,15)

Upstream product

• 169280-83-5 (5-hydroxymethylpyridin-2-yl)-carbamic acid t-butyl ester 
• 36052-24-1 methyl 6-aminonicotinoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3167-49-5 6-aminonicotinic acid 
• 144186-11-8 methyl 6-<(tert-butyloxycarbonyl)amino>nicotinoate 
• 68-12-2 N,N-dimethyl-formamide 
• 159451-66-8 tert-butyl N-(5-bromopyridin-2-yl)carbamate 
• 69879-22-7 6-amino-3-pyridinecarbaldehyde 
• 201230-82-2 carbon monoxide 

Downstream Products

• 169280-83-5 (5-hydroxymethylpyridin-2-yl)-carbamic acid t-butyl ester 
• 1620092-98-9 (E)-2-(tert-butoxycarbonylamino)-5-(2,6-difluorostyryl)pyridine 
• 1375150-70-1 (Z)-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid ethyl ester 
• 1375150-69-8 (E)-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid ethyl ester 
• 1375150-73-4 (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid 
• 1375150-71-2 (E)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid 
• 497159-99-6 dimethyl 2-({6-[(tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)-2-{1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}malonate 
• 1620092-86-5 (E)-5-(2,6-difluorostyryl)-2-(N-ethylamino)pyridine 
• 1620092-99-0 (E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine 

Relevant articles and documents

Intermediate for preparing pexidartinib, and preparation method and application thereof

The invention discloses an intermediate for preparing pexidartinib, a preparation method and application thereof. According to the invention, raw materials and reagents used in the method are cheap and easily available, the ultralow-temperature reaction and corrosive trifluoroacetic acid are successfully avoided, the method has low requirements on equipment and is beneficial to energy conservationand emission reduction, the preparation process of pexidartinib and related intermediates is simple to operate, post-treatment and purification are convenient, column chromatography is not needed, and the total yield is up to 48%; according to the method, a compound (IV) is prepared from a compound (II), a compound (V) is prepared from a compound (IV), and pexidartinib is prepared, so that the defects and deficiencies of preparation methods reported in literatures are overcome; and the intermediate for preparing pexidartinib is a compound with a structure represented by a formula (A1), a compound with a structure represented by a formula (II) or a compound with a structure represented by a formula (IV).

SPIROCYCLIC HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula (IX) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives

Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives The present invention relates to a process for the preparation of a compound of the formula (I), which comprises reacting a compound of the formula IV, (IV) with the compound of formula VII R15-A2-CHO and to novel intermediate compounds used therein.