137530-41-7

Basic information

• Product Name: Aids005680
• Synonyms: (+)-(2S,5R)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine;(+)-2'-Deoxy-5-flouro-3'-thiacytidine;2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-;5Fc-(+).B.;Aids005680;Aids-005680;oxathiolan;4-AMino-5-fluoro-1-[(2S,5R)-2-(hydroxyMethyl)-1,3-oxathiolan-5-yl]- 2(1H)-pyriMidinone
• CAS NO: 137530-41-7
• Molecular Formula: C8H10FN3O3S
• Molecular Weight: 247.2467032
• Product Categories: Carbohydrates & Derivatives;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 137530-41-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 443.3±55.0 °C(Predicted)
• Appearance: /
• Density: 1.82±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 13.83±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Aids005680(CAS DataBase Reference)
• NIST Chemistry Reference: Aids005680(137530-41-7)
• EPA Substance Registry System: Aids005680(137530-41-7)

Safety Data

• Hazardous Substances Data: 137530-41-7(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

Different sources of media describe the Uses of 137530-41-7 differently. You can refer to the following data:
1. A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).
2. As a reverse transcriptase inhibitor, ent-EMtricitabine is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).

Upstream product

• 144371-00-6 (+/-)-cis-2',3'-dideoxy-5-fluoro-3'-thiacytidine 
• 149819-36-3 (+)-(2S,5R)-5-fluoro-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N₄-benzoylcytosine 

Relevant articles and documents

Preparation method for emtricitabine isomer

The invention discloses a preparation method for an embritabine isomer. The preparation method comprises the following steps: with Solketal as a starting material, allowing the Solketal to undergo a six-step reaction of esterification, hydrolysis, oxidation, condensation cyclization, acetylation and glycosylation condensation so as to synthesize four mixture intermediates of emtricitabine; and splitting the four isomer intermediates into a cis-isomer mixture and a trans-isomer mixture through a chiral reagent. According to the invention, by adoption of a simple starting material, a mixture forsplitting key intermediates of four optical isomers of the emtricitabine is synthesized through the six-step reaction, and chiral acid is utilized to split the four isomers into a mixture of cis andtrans isomers, so the preparation method provided by the invention has the advantages of simple and convenient operation, high yield and high isomer chiral purity.

Processes for the diastereoselective synthesis of nucleoside analogues

The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity, and intermediates useful in those processes.