137531-66-9

Upstream product

• 583-60-8 2-Methylcyclohexanone 
• 63883-66-9 2-methylcyclohexanone (2,4,6-triisopropylphenyl)sulphonylhydrazone 
• 80360-23-2 1-(phenylsulfonyl)-1H-indole-2-carbaldehyde 

Downstream Products

• 132430-79-6 7β-Methyl-6-oxo-5-phenylsulphonyl-5,6,6aβ,7,8,9,10,10aβ-octahydroindeno<2,1-b>indole 
• 137531-69-2 7β-Methyl-5-phenylsulphonyl-5,6,6aβ,7,8,9,10,10aβ-octahydroindeno<2,1-b>indol-6α-ol 
• 137531-70-5 6β-(Indol-3'-yl)-7β-methyl-5-phenylsulphonyl-5,6,6aβ,7,8,9,10,10aβ-octahydroindeno<2,1-b>indole 
• 137531-72-7 7β-Methyl-6β-(2'-methylindol-3'-yl)-phenylsulphonyl-5,6,6aβ,7,8,9,10,10aβ-octahydroindeno<2,1-b>indole 
• 132430-79-6 (6aS,7S,10aR)-5-Benzenesulfonyl-7-methyl-6a,7,8,9,10,10a-hexahydro-5H-indeno[2,1-b]indol-6-one 
• 137531-68-1 6-Methylcyclohex-1-enyl 1'-Phenylsulphonylindol-2'-yl Ketone 

Relevant academic research and scientific papers

New General Approach to the Synthesis of Yuehchukene Analogues. Stereoselective Synthesis of 9,10-Dihydro-7α,9-didemethylyuehchukene. X-Ray Molecular Structure of 6β-(Indol-3'-yl)-7β-methyl-5-phenylsulphonyl-5,6,6aβ,7,8,9,10,10aβ-octahydroindenoindole

A versatile synthetic strategy for the syntheses of the yuehchukene analogues 6β-(indol-3'-yl)-7β-methyl-5,6,6aβ,7,8,9,10,10aβ-octahydroindenoindole and 7β-methyl-6β-(2'-methylindol-3'-yl)-5,6,6aβ,7,8,9,10,10aβ-octahydroindenoindole is described.The key reactions involve trapping of the vinyllithium derivative 6-methylcyclohex-1-enyllithium, generated from the trisylhydrazone of 2-methylcyclohexanone, with indole-2-carbaldehyde, and Nazarov cyclization of the α,β-unsaturated 2-acylindole 6-methylcyclohex-1-enyl N-phenylsulphonylindol-2-yl ketone.

Facile Synthesis of 6-Oxo-5,6,6αβ,7,8,9,10,10αβ-octahydroindenoindole System

A facile stereoselective synthesis of 6-oxo-5,6,6αβ,7,8,9,10,10αβ-octahydroindenoindole, the key intermediate for yuehchukene analogues synthesis, is described.