63883-66-9Relevant academic research and scientific papers
New General Approach to the Synthesis of Yuehchukene Analogues. Stereoselective Synthesis of 9,10-Dihydro-7α,9-didemethylyuehchukene. X-Ray Molecular Structure of 6β-(Indol-3'-yl)-7β-methyl-5-phenylsulphonyl-5,6,6aβ,7,8,9,10,10aβ-octahydroindenoindole
Cheng, Kin-Fai,Chan, Kwok-Pong,Lai, Ting-Fong
, p. 2461 - 2465 (2007/10/02)
A versatile synthetic strategy for the syntheses of the yuehchukene analogues 6β-(indol-3'-yl)-7β-methyl-5,6,6aβ,7,8,9,10,10aβ-octahydroindenoindole and 7β-methyl-6β-(2'-methylindol-3'-yl)-5,6,6aβ,7,8,9,10,10aβ-octahydroindenoindole is described.The key reactions involve trapping of the vinyllithium derivative 6-methylcyclohex-1-enyllithium, generated from the trisylhydrazone of 2-methylcyclohexanone, with indole-2-carbaldehyde, and Nazarov cyclization of the α,β-unsaturated 2-acylindole 6-methylcyclohex-1-enyl N-phenylsulphonylindol-2-yl ketone.
Facile Synthesis of 6-Oxo-5,6,6αβ,7,8,9,10,10αβ-octahydroindenoindole System
Cheng, Kin-Fai,Chan, Kwok-Pong
, p. 3069 - 3076 (2007/10/02)
A facile stereoselective synthesis of 6-oxo-5,6,6αβ,7,8,9,10,10αβ-octahydroindenoindole, the key intermediate for yuehchukene analogues synthesis, is described.
Silicon-Directed Nazarov Reactions II. Preparation and Cyclization of β-Silyl-substituted Divinyl Ketones
Jones, Todd K.,Denmark, Scott E.
, p. 2377 - 2396 (2007/10/02)
Two general methods for the preparation of β-silyl-substituted divinyl ketones have been developed starting from either α,β-unsaturated aldehydes or simple ketones.Anhydrous FeCl3 induces the cyclization to cyclopentenones under mild conditions and in good yields with predictable and complete control over the position of the double bond in the five-membered ring.The observed effects of substituents on rate can be explained by a rate-determining cationic electrocyclization.Silyl substitution has been shown to retard the reaction.
ENEPHOSPHINILATION
Mislankar, Dattatraya G.,Mugrage, Ben,Darling, S. D.
, p. 4619 - 4622 (2007/10/02)
A general method is described for the formation of vinylphosphines from arylsulfonylhydrazones.Oxidation of the resulting vinylphosphines yields phosphine oxides.
NITRODESTANNYLATION. A NEW SYNTHESIS OF CONJUGATED NITRO CYCLO OLEFINS
Corey, E. J.,Estreicher, Herbert
, p. 1113 - 1116 (2007/10/02)
A new process for the conversion of cyclic ketones to 1-nitro olefines, as outlined in eq. 2 below, is described.
