1375313-74-8

Upstream product

• 1375313-64-6 11-(1H-benzo[d][1,2,3]triazol-1-yloxy)-N-(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)undecanamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 1677-46-9 4-hydroxy-1-methyl-2(1H)-quinolone 
• 36949-55-0 4-hydroxy-1-methyl-3-nitro-2-(1H)quinolinone 
• 70744-03-5 3-amino-4-hydroxy-1-methyl-1H-quinolin-2-one 

Relevant academic research and scientific papers

Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives

A new family of quinolinone derivatives has been synthesized and evaluated for their antikinetoplastid activities against Leishmania donovani and Trypanosoma brucei brucei. Results from these structure-activity relationship studies enabled identification of compounds 3a and 4g as the most active compounds against L. donovani promastigotes and amastigotes parasites (IC 50 values in a range of 2-11 μM). Additionally, compound 3b has emerged from this study as the most active compound in the series against T. b. brucei with a MEC value of 12 μM. These three compounds are worth of further in vivo evaluation.