1375313-78-2

Basic information

• Product Name: 3-(4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)-1-methylquinolin-2(1H)-one
• Synonyms: 3-(4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)-1-methylquinolin-2(1H)-one
• CAS NO: 1375313-78-2
• Molecular Weight: 320.326
• Mol File: 1375313-78-2.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)-1-methylquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)-1-methylquinolin-2(1H)-one(1375313-78-2)
• EPA Substance Registry System: 3-(4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)-1-methylquinolin-2(1H)-one(1375313-78-2)

Safety Data

• Hazardous Substances Data: 1375313-78-2(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 1314641-17-2 C₁₀H₈N₄O 

Relevant articles and documents

An efficient synthesis of 3-triazolyl-2(1H)-quinolones by CuTC-catalyzed azide-alkyne cycloaddition reaction

A facile and efficient Cu(I)-catalyzed azide-alkyne cycloaddition reaction for the synthesis of a series of 3-triazolyl-2(1H)-quinolones 3 have been developed using 3-azido-quinolin-2(1H)-one as the coupling partner. The optimized reaction conditions involve the use of eco- friendly ethanol as the solvent in the presence of copper(I) thiophene-2-carboxylate as the catalyst, to afford good to excellent yields of 3-triazolyl-2(1H)-quinolone derivatives of biological interest. Copyright

Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives

A new family of quinolinone derivatives has been synthesized and evaluated for their antikinetoplastid activities against Leishmania donovani and Trypanosoma brucei brucei. Results from these structure-activity relationship studies enabled identification of compounds 3a and 4g as the most active compounds against L. donovani promastigotes and amastigotes parasites (IC 50 values in a range of 2-11 μM). Additionally, compound 3b has emerged from this study as the most active compound in the series against T. b. brucei with a MEC value of 12 μM. These three compounds are worth of further in vivo evaluation.