137532-01-5

Upstream product

• 137532-00-4 (S)-3-(m-benzyloxymethoxyphenyl)propane-1,3-diol 
• 74-88-4 methyl iodide 
• 3587-60-8 Benzyloxymethyl chloride 
• 155433-48-0 Toluene-4-sulfonic acid (S)-3-(3-benzyloxymethoxy-phenyl)-3-hydroxy-propyl ester 
• 14755-02-3 3-hydroxy-trans-cinnamic acid 
• 137531-98-7 m-benzyloxymethoxycinnamyl alcohol 
• 155433-47-9 (E)-3-(3-Benzyloxymethoxy-phenyl)-acrylic acid ethyl ester 
• 137531-99-8 (2R,3R)-3-(m-benzyloxymethoxyphenyl)-2,3-epoxypropan-1-ol 

Downstream Products

• 137531-89-6 (2R,3R,4R,5S,8S)-8-(m-benzyloxymethylphenyl)-1,2-epoxy-8-methoxy-3,5-dimethyloctan-4-ol 
• 110314-58-4 (2R,3R,4R,5S,8S)-8--1,2-epoxy-8-methoxy-4-(p-methoxybenzyloxy)-3,5-dimethyloctane 
• 137531-88-5 (2S,3R,4R,5S,8S)-8-(m-benzyloxymethoxyphenyl)-8-methoxy-3,5-dimethyl-2-(2-tetrahydropyranyloxy)octane-1,4-diol 
• 137531-90-9 (2R,3R,8S,9S,10R,11S,14S)-14--1,2-isopropylidenedioxy-14-methoxy-10-(p-methoxybenzyloxy)-6,6-propylenedithio-3,5,5,9,11-pentamethyltetra-decan-8-ol 
• 137531-93-2 (3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-1-[2-((R)-1,1,3-trimethyl-4-oxo-butyl)-[1,3]dithian-2-ylmethyl]-heptyl ester 
• 137531-92-1 (2R,3R,8S,9S,10R,11S,14S)-14--1,2-isopropylidenedioxy-14-methoxy-10-(p-methoxybenzyloxy)-6,6-propylenedithio-3,5,5,9,11-pentamethyltetradecan-8-yl (3R,4R)-4-benzyloxymethoxy-3-(p-methoxybenzyloxy)pentanoate 
• 137531-87-4 (2S,3R,4R,5R,8S)-8-(m-benzyloxymethoxyphenyl)-1-(tert-butyldimethylsiloxy)-5-hydroxymethyl-8-methoxy-3-methyl-2-(2-tetrahydropyranyloxy)octan-4-ol 
• 155433-69-5 Kishi's aldehyde 
• 155433-57-1 (2R,3R,4R,5S,8S)-8--1,2-isopropylidenedioxy-8-methoxy-3,5-dimethyloctan-4-ol 
• 155433-56-0 (2R,3R,4R,5R,8S)-8--5-hydroxymethyl-1,2-isopropylidene-dioxy-8-methoxy-3-methyloctan-4-ol 
• 155433-66-2 Acetic acid (1R,2S,5S)-1-((1S,2S)-3-acetoxy-2-hydroxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester 
• 155433-58-2 (2R,3R,4R,5S,8S)-8--1,2-isopropylidenedioxy-8-methoxy-4-(p-methoxybenzyloxy)-3,5-dimethyloctane 
• 155433-67-3 Acetic acid (1R,2S,5S)-1-((1R,2S)-3-acetoxy-2-methanesulfonyloxy-1-methyl-propyl)-5-(3-benzyloxymethoxy-phenyl)-5-methoxy-2-methyl-pentyl ester 

Relevant academic research and scientific papers

A Formal Synthesis of Aplysiatoxin: Enantioselective Synthesis of Kishi's Aldehyde

This paper describes the enantioselective synthesis of key fragments (12,18,24, and 35) for the synthesis of aplysiatoxin (1a), a potent cancer promoter, and their convergent assembly to Kishi's aldehyde (2).Since 2 has already been transformed into 1a in

SYNTHESIS OF APLYSIATOXIN: STEREOSELECTIVE SYNTHESIS OF KEY FRAGMENTS

Stereoselective synthesis of key fragments for the synthesis of aplysiatoxin has been achieved.All the stereogenic carbons contained in fragments B-E were elaborated on the basis of Wittig rearrangement and titanium-mediated asymmetric epoxidation.