137537-95-2Relevant academic research and scientific papers
Enantioselective Total Synthesis of Ginkgolide Derivatives Lacking the tert-Butyl Group, an Essential Structural Subunit for Antagonism of Platelet Activating Factor
Corey, E. J.,Rao, K. Srinivas
, p. 4623 - 4626 (1991)
An enantioselective total synthesis of the ginkgolide B analog 3 is reported along with results of bioassays for antagonism of platelet activating factor.The three orders of magnitude difference in bioactivity of 2 and 3 demonstrates that the tert-butyl group of the ginkgolides is essential for anti-PAF potency.
