Tetrahedron Letters p. 4623 - 4626 (1991)
Update date:2022-08-03
Topics:
Corey, E. J.
Rao, K. Srinivas
An enantioselective total synthesis of the ginkgolide B analog 3 is reported along with results of bioassays for antagonism of platelet activating factor.The three orders of magnitude difference in bioactivity of 2 and 3 demonstrates that the tert-butyl group of the ginkgolides is essential for anti-PAF potency.
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