1375415-15-8

Upstream product

• 99-81-0 4-Nitrophenacyl bromide 
• 536-74-3 phenylacetylene 
• 26086-61-3 2-azido-1-(4-nitrophenyl)ethan-1-one 

Downstream Products

• 1217271-85-6 1-(4-nitrophenyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethanol 
• 1255944-41-2 (R)-1-(4-nitrophenyl)-2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethanol 

Relevant academic research and scientific papers

Catalytically active nanorotor reversibly self-assembled by chemical signaling within an eight-component network

A catalytically active three-component nanorotor is reversibly self-assembled and disassembled by remote control. When zinc(ii) ions (2 equiv.) are added as an external chemical trigger to the mixture of transmitter [Cu(1)]+ and pre-rotor assembly [(S)·(R)], two equiv. of copper(i) ions translocate from [Cu(1)]+ to the two phenanthroline sites of [(S)·(R)]. As a result, [Zn(1)]2+ forms along with the three-component assembly [Cu2(S)(R)]2+, which is both a nanorotor (k298 = 46 kHz, ΔH? = 49.1 ± 0.4 kJ mol-1, ΔS? = 9.5 ± 1.7 J mol-1 K-1) and a catalyst for click reactions (catalysis ON: A + B→AB). Removal of zinc from the mixture reverts the translocation sequence and thus commands disassembly of the catalytically active rotor (catalysis OFF). The ON/OFF catalytic cycle was run twice in situ in the full network.

Double Rotors with Fluxional Axles: Domino Rotation and Azide–Alkyne Huisgen Cycloaddition Catalysis

The simple preparation of the multicomponent devices [Cu4(A)2]4+ and [Cu2(A)(B)]2+, both rotors with fluxional axles undergoing domino rotation, highlights the potential of self-sorting. The concept of domino rotation requires the interconversion of axle and rotator, allowing the spatiotemporal decoupling of two degenerate exchange processes in [Cu4(A)2]4+ occurring at 142 kHz. Addition of two equiv of B to rotor [Cu4(A)2]4+ afforded the heteromeric two-axle rotor [Cu2(A)(B)]2+ with two distinct exchange processes (64.0 kHz and 0.55 Hz). The motion requiring a pyridine→zinc porphyrin bond cleavage is 1.2×105 times faster than that operating via a terpyridine→[Cu(phenAr2)]+ rupture. Finally, both rotors are catalysts due to their copper(I) content. The fast domino rotor (142 kHz) was shown to suppress product inhibition in the catalysis of the azide–alkyne Huisgen cycloaddition.

A Metalloregulated Four-State Nanoswitch Controls Two-Step Sequential Catalysis in an Eleven-Component System

The nanomechanical switch 1 with its three orthogonal binding motifs—the zinc(II) porphyrin, azaterpyridine, and shielded phenanthroline binding station—is quantitatively and reversibly toggled back and forth between four different switching states by mea

Design and synthesis of magnetic Fe3O4?NFC-ImSalophCu nanocatalyst based on cellulose nanofibers as a new and highly efficient, reusable, stable and green catalyst for the synthesis of 1,2,3-triazoles

The Fe3O4?NFC-ImSalophCu catalyst was used as a highly stable, reusable, active, green catalyst for the synthesis of 1,2,3-triazolesviaone-pot three-component reaction of phenacyl bromides, sodium azide and alkynes. A Cu(ii)-Schiff base complex containing an imidazolium ionic phase was prepared and decorated on core shell Fe3O4?NFC magnetic nanoparticles (Fe3O4?NFC-ImSalophCu) and was used as an efficient catalyst. The heterogeneous catalyst was characterized by FT-IR spectroscopy, FE-SEM, TEM, XRD spectroscopy, EDX spectroscopy, VSM, and ICP spectroscopy. This catalyst shows the dual function of the metal sites and imidazolium moieties. The catalytic system mentioned above also showed excellent activity in the synthesis of bis 1,4-disubstituted 1,2,3-triazoles. Moreover, the catalyst could be recycled and reused for four cycles without any decrease in its catalytic activity.

Synthesis and Characterization of Copper(I)‐Cysteine Complex Supported on Magnetic Layered Double Hydroxide as an Efficient and Recyclable Catalyst System for Click Chemistry Using Choline Azide as Reagent and Reaction Medium

Abstract: In this study, Fe3O4@LDH@cysteine–Cu(I) nanoparticles as a novel and recyclable catalytic system was designed and successfully synthesized. These nanoparticles show high catalytic activity for preparation of the triazole fa

Enantioselective separation of (±)-β-hydroxy-1,2,3-triazoles by supercritical fluid chromatography and high-performance liquid chromatography

This paper reports the enantioseparation of β-hydroxy-1,2,3-triazole derivatives, which present a broad range of biological properties, by supercritical fluid chromatography (SFC) and high-performance liquid chromatography techniques (HPLC). Polysaccharid

Copper(I)–Caffeine Complex Immobilized on Silica-Coated Magnetite Nanoparticles: A Recyclable and Eco-friendly Catalyst for Click Chemistry from Organic Halides and Epoxides

Abstract: Copper(I)–caffeine complex immobilized on silica-coated magnetite nanoparticles was successfully synthesized and fully characterized by analyzing FT-IR, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray, inductively couple

Copper(II) bis-thiazole complex immobilized on silica nanoparticles: Preparation, characterization and its application as a highly efficient catalyst for click synthesis of 1,2,3-triazoles

In this work, the preparation of copper(II) complex of 3,5-bis(2-benzothiazolyl)pyridine, Cu(II)Br2-BTP, supported on nano silica functionalized with trimethoxysilylpropylchloride, Cu(II)Br2-BTP@TMSP-nSiO2, is reported. Th

Catalytic asymmetric synthesis of β-triazolyl amino alcohols by asymmetric transfer hydrogenation of α-triazolyl amino alkanones

The synthesis of optically active β-triazolyl amino alcohols was carried out via ruthenium catalyzed asymmetric transfer hydrogenation of α-triazolyl amino alkanones. This reaction proceeds under mild reaction conditions with up to 99% yield and 99.9% ena

Polystyrene-supported ionic liquid copper complex: A reusable catalyst for one-pot three-component click reaction

Copper(II) complex of 1,2-bis(4-pyridylthio)ethane immobilized on polystyrene was a used as a highly stable, active, reusable and green catalyst for click synthesis of 1,2,3-triazoles via one-pot three-component reaction of organic halides, sodium azide a