1375476-71-3Relevant academic research and scientific papers
Copper-catalyzed synthesis of indolyl diketones: Via C-H oxidation/diacylation of indoles with arylglyoxal hydrates
Wang, Cuiping,Zhang, Zhiqiang,Liu, Kui,Yan, Jingbo,Zhang, Tiexin,Lu, Gonghao,Meng, Qingtao,Chi, Haijun,Duan, Chunying
, p. 6185 - 6193 (2017)
An expedient protocol for Cu-catalyzed C-H oxidation/diacylation of indoles with arylglyoxal hydrates to construct indolyl diketones is developed. This methodology exhibits the synthetic utility of the synthesis of an indole-alkaloid 1,2-di(1H-indol-3-yl)ethane-1,2-dione and offers a straightforward means to produce different indolyl nitrogen-containing heterocycles such as indolyl quinoxaline, indolyl hydantoin and indolyl imidazole in high yields. Preliminary mechanistic studies indicate that two proposed pathways are involved in this process.
A Regioselective Approach to Synthesize Indolyl Diketone Derivatives via Magnetic Polymeric Copper-Catalyst
Jarahiyan, Atefeh,Moghaddam, Firouz Matloubi,Pourjavadi, Ali
, (2021/06/21)
Abstract: In the present paper, an efficient Cu-catalyzed regioselective acylation of indoles with phenylglyoxals was developed which is the first example of indolyl diketones synthesis by a heterogeneous catalyst. The magnetic polyacrylonitrile was synth
Synthesis of 3-acylated indoles through iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds
Yi, Niannian,Li, Jinxia,Zhang, Hao,Wang, Ruijia,Jiang, Jun,Deng, Wei,Zeng, Zebing,Xiang, Jiannan
supporting information, p. 2062 - 2069 (2017/10/13)
A novel iron-catalyzed oxidative coupling of indoles with α-amino carbonyl compounds has been developed. The transformation provides an attractive approach to the synthesis of 3-acylindoles, with the advantages of easily available starting materials and high functional group tolerance. Furthermore, control experiments imply that a radical process maybe involved in this reaction.
3-dicarbonyl substitution indole compound and preparation method thereof
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Paragraph 0015; 0016; 0023; 0024, (2016/10/09)
The invention discloses a 3-dicarbonyl substitution indole compound and a preparation method thereof, and belongs to the technical field of synthesis of indole derivatives. According to the technical scheme, the 3-dicarbonyl substitution indole compound i
Copper-catalyzed C-H oxidation/cross-coupling of α-amino carbonyl compounds
Wu, Ji-Cheng,Song, Ren-Jie,Wang, Zhi-Qiang,Huang, Xiao-Cheng,Xie, Ye-Xiang,Li, Jin-Heng
supporting information; experimental part, p. 3453 - 3457 (2012/06/01)
Keeping options open: The new and mild title reaction involving indoles selectively furnishes 1 and 2 with the aid of tert-butyl hydroperoxide (TBHP). The method represents the first example of a copper-catalyzed α arylation of α-amino carbonyl substrates leading to α-aryl α-imino and α-aryl α-oxo carbonyl compounds using a C-H oxidation strategy. Copyright
