137548-56-2 Usage
Uses
Used in Cancer Research:
2,4-dibromo-17-acetylestradiol is used as a research tool for studying the inhibition of estrogen-sensitive tumor growth. Its potential to target and affect the development of certain types of cancer has made it a subject of interest in oncology.
Used in Hormone Replacement Therapy:
2,4-dibromo-17-acetylestradiol is being investigated for its potential use in hormone replacement therapy, where it could serve as an alternative or adjunct to existing treatments, particularly for conditions related to estrogen deficiency.
Used in Studying Estrogen Receptor Signaling Pathways:
2,4-dibromo-17-acetylestradiol is utilized as a research agent to understand the mechanisms of estrogen receptor signaling, which is crucial for developing a deeper comprehension of estrogen-related physiological processes and diseases.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 2,4-dibromo-17-acetylestradiol is used as a lead compound for the development of new drugs targeting estrogen receptors, potentially leading to novel therapeutics for various conditions influenced by estrogen levels.
Check Digit Verification of cas no
The CAS Registry Mumber 137548-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,5,4 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 137548-56:
(8*1)+(7*3)+(6*7)+(5*5)+(4*4)+(3*8)+(2*5)+(1*6)=152
152 % 10 = 2
So 137548-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H24Br2O3/c1-10(23)20(25)8-6-15-12-3-4-13-14(9-16(21)18(24)17(13)22)11(12)5-7-19(15,20)2/h9,11-12,15,24-25H,3-8H2,1-2H3/t11-,12+,15-,19-,20+/m0/s1
137548-56-2Relevant academic research and scientific papers
Nucleophilic addition to the ethynyl group in ethynylestradiol catalyzed by crown ether-copper (1) iodide
Chen, Shu-hua,Luo, Guang-rong,Chang, Xiu-zhen,Zhao, Hua-ming
, p. 533 - 535 (2007/10/02)
A new and convenient synthetic route to acetylation of estrogens is described.Benzo-15-crown-5 and cuprous iodide-mixed catalyst catalyzed the nucleophilic addition of 2,4-dibromoethynylestradiol, resulting in the formation of a new compound, 2,4-dibromo-17α-acetylestradiol, of which the structure was characterized by infrared, UV, 1H nuclear magnetic resonance, mass spectra, and elemental analysis.It was found that the yield of this approach is much higher than that obtained in the hydration of usual acetylenic compounds. Keywords: steroids; ethynylestradiol; acetylation; hydration; crown ether; nucleophilic addition; 17α-acetylestradiol; catalyst, CR-CuI; 2,4-dibromoethynylestradiol
