79769-52-1 Usage
General Description
2,4-dibromo-17-ethynyl(6,7)estradiol is a synthetic derivative of the hormone estradiol, which is a form of estrogen. It is a potent estrogen receptor ligand and has been used in research as a tool to study estrogen receptor function. This chemical is often used in vitro experiments to investigate the effects of estrogen on cellular processes and has been found to have high affinity and selectivity for estrogen receptors. Additionally, it has been studied for its potential therapeutic use in hormone-related conditions such as osteoporosis and breast cancer. However, caution should be taken when handling 2,4-dibromo-17-ethynyl(6,7)estradiol, as it is a hazardous chemical that requires proper safety protocols and protective equipment.
Check Digit Verification of cas no
The CAS Registry Mumber 79769-52-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,7,6 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 79769-52:
(7*7)+(6*9)+(5*7)+(4*6)+(3*9)+(2*5)+(1*2)=201
201 % 10 = 1
So 79769-52-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H22Br2O2/c1-3-20(24)9-7-15-12-4-5-13-14(10-16(21)18(23)17(13)22)11(12)6-8-19(15,20)2/h1,10-12,15,23-24H,4-9H2,2H3/t11-,12+,15-,19-,20-/m0/s1
79769-52-1Relevant academic research and scientific papers
Chen, Shu-hua,Luo, Guang-rong,Chang, Xiu-zhen,Zhao, Hua-ming
, p. 533 - 535 (1991)
A new and convenient synthetic route to acetylation of estrogens is described.Benzo-15-crown-5 and cuprous iodide-mixed catalyst catalyzed the nucleophilic addition of 2,4-dibromoethynylestradiol, resulting in the formation of a new compound, 2,4-dibromo-17α-acetylestradiol, of which the structure was characterized by infrared, UV, 1H nuclear magnetic resonance, mass spectra, and elemental analysis.It was found that the yield of this approach is much higher than that obtained in the hydration of usual acetylenic compounds. Keywords: steroids; ethynylestradiol; acetylation; hydration; crown ether; nucleophilic addition; 17α-acetylestradiol; catalyst, CR-CuI; 2,4-dibromoethynylestradiol
