1375544-48-1

Basic information

• Product Name: N-{4-[(tetrahydrofuran-3-ylmethyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide
• CAS NO: 1375544-48-1
• Molecular Weight: 365.432
• Mol File: 1375544-48-1.mol

Chemical Properties

• CAS DataBase Reference: N-{4-[(tetrahydrofuran-3-ylmethyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{4-[(tetrahydrofuran-3-ylmethyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide(1375544-48-1)
• EPA Substance Registry System: N-{4-[(tetrahydrofuran-3-ylmethyl)carbamoyl]phenyl}-1,3-dihydro-2H-isoindole-2-carboxamide(1375544-48-1)

Safety Data

• Hazardous Substances Data: 1375544-48-1(Hazardous Substances Data)

Upstream product

• 23138-53-6 methyl 4-isocyanatobenzoate 
• 496-12-8 isoindoline 
• 1375745-18-8 4-(2H-isoindoline-2-carboxamido)benzoic acid 
• 165253-31-6 (tetrahydro-3-furanyl)methylamine 
• 1375745-17-7 methyl 4-(isoindoline-2-carboxamido)benzoate 

Relevant articles and documents

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)

Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. Modification of the isoindoline and/or the terminal functiona

NAMPT AND ROCK INHIBITORS

Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the co