1375692-41-3Relevant articles and documents
Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents
Wang, Li-Jun,Geng, Chang-An,Ma, Yun-Bao,Huang, Xiao-Yan,Luo, Jie,Chen, Hao,Zhang, Xue-Mei,Chen, Ji-Jun
supporting information; experimental part, p. 3473 - 3479 (2012/07/03)
Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.