1375744-91-4

Basic information

• Product Name: (2S)-2-[benzyl(phenoxycarbonyl)amino]propanoic acid
• CAS NO: 1375744-91-4
• Molecular Weight: 299.326
• Mol File: 1375744-91-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-2-[benzyl(phenoxycarbonyl)amino]propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-[benzyl(phenoxycarbonyl)amino]propanoic acid(1375744-91-4)
• EPA Substance Registry System: (2S)-2-[benzyl(phenoxycarbonyl)amino]propanoic acid(1375744-91-4)

Safety Data

• Hazardous Substances Data: 1375744-91-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 

Downstream Products

• 1375744-73-2 3-benzoyl-1-benzyl-4-[(4-methoxyphenyl)methyl]-6-methylpiperazine-2,5-dione 
• 1375744-90-3 N-benzyl-N-[(2S)-1-chloro-1-oxopropan-2-yl]carbamate 
• 1375744-74-3 phenyl N-benzyl-N-[(1S)-1-{[(4-methoxyphenyl)methyl](2-oxo-2-phenethyl)carbamoyl}ethyl]carbamate 
• 1375744-92-5 phenyl N-benzyl-N-[(1S)-1-[(2-hydroxy-2-phenethyl)[(4-methoxyphenyl)methyl]-carbamoyl]ethyl]carbamate 

Relevant articles and documents

A Dieckmann cyclization route to piperazine-2,5-diones

Piperazine-2,5-diones are formed by Dieckmann cyclization (NaH, THF) of substructures of the type CH2-N(R)C(O)CH2N(R′) CO2Ph in which the terminal methylene (CH2) that is adjacent to nitrogen closes onto the carbonyl group of the phenyl carbamate unit at the other end of the chain. R and R′ are alkyl groups, and the terminal methylene is activated by a ketone carbonyl, a nitrile, an ester, or a phosphoryl group. The starting materials are assembled by standard acylation and oxidation processes, starting from a β-(alkylamino)alcohol, an (alkylamino)acetonitrile, an (alkylamino) ester, or an (alkylamino)methyl phosphonate.