1375745-11-1

Basic information

• Product Name: 4-nitrophenyl N-(2-chloro-2-oxoethyl)-N-methylcarbamate
• Synonyms: 4-nitrophenyl N-(2-chloro-2-oxoethyl)-N-methylcarbamate
• CAS NO: 1375745-11-1
• Molecular Weight: 272.645
• Mol File: 1375745-11-1.mol

Chemical Properties

• CAS DataBase Reference: 4-nitrophenyl N-(2-chloro-2-oxoethyl)-N-methylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrophenyl N-(2-chloro-2-oxoethyl)-N-methylcarbamate(1375745-11-1)
• EPA Substance Registry System: 4-nitrophenyl N-(2-chloro-2-oxoethyl)-N-methylcarbamate(1375745-11-1)

Safety Data

• Hazardous Substances Data: 1375745-11-1(Hazardous Substances Data)

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 1375745-12-2 2-[methyl(4-nitrophenoxycarbamoyl)amino]acetic acid 

Downstream Products

• 1375744-88-9 4-nitrophenyl N-({[(4-methoxyphenyl)methyl](2-oxo-2-phenylethyl)carbamoyl}-methyl)-N-methylcarbamate 
• 1375744-64-1 4-nitrophenyl N-{[benzyl(2-oxo-2-phenylethyl)carbamoyl]methyl}-N-methylcarbamate 
• 1375744-84-5 4-nitrophenyl N-{[benzyl(2-hydroxy-2-phenylethyl)carbamoyl]methyl}-N-methylcarbamate 

Relevant articles and documents

A Dieckmann cyclization route to piperazine-2,5-diones

Piperazine-2,5-diones are formed by Dieckmann cyclization (NaH, THF) of substructures of the type CH2-N(R)C(O)CH2N(R′) CO2Ph in which the terminal methylene (CH2) that is adjacent to nitrogen closes onto the carbonyl group of the phenyl carbamate unit at the other end of the chain. R and R′ are alkyl groups, and the terminal methylene is activated by a ketone carbonyl, a nitrile, an ester, or a phosphoryl group. The starting materials are assembled by standard acylation and oxidation processes, starting from a β-(alkylamino)alcohol, an (alkylamino)acetonitrile, an (alkylamino) ester, or an (alkylamino)methyl phosphonate.