1375799-69-1

Basic information

• Product Name: (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-4,6-dihydropyrrolo[3,4c]pyrazole-5(1H)-carboxylate-
• CAS NO: 1375799-69-1
• Molecular Weight: 481.518
• Mol File: 1375799-69-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-4,6-dihydropyrrolo[3,4c]pyrazole-5(1H)-carboxylate-(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-4,6-dihydropyrrolo[3,4c]pyrazole-5(1H)-carboxylate-(1375799-69-1)
• EPA Substance Registry System: (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-4,6-dihydropyrrolo[3,4c]pyrazole-5(1H)-carboxylate-(1375799-69-1)

Safety Data

• Hazardous Substances Data: 1375799-69-1(Hazardous Substances Data)

Upstream product

• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 1375799-75-9 ethyl 5-(chlorocarbonyl)-6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-5,6-dihydropyrrolo[3,4-c]pyrazole-1(4H)-carboxylate 
• 2202-68-8 (S)-2-dimethylamino-1-phenylethanol 
• 1376434-97-7 ethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-5,6-dihydropyrrolo[3,4-c]pyrazole-1(4H)-carboxylate 
• 1375799-73-7 5-tert-butyl 1-ethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)pyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate 
• 718632-40-7 methyl 2-[(tert-butoxycarbonyl)(2-cyanoethyl)amino]-2-methylpropanoate 

Relevant articles and documents

Discovery of pyrroloaminopyrazoles as novel PAK inhibitors

The P21-activated kinases (PAK) are emerging antitumor therapeutic targets. In this paper, we describe the discovery of potent PAK inhibitors guided by structure-based drug design. In addition, the efflux of the pyrrolopyrazole series was effectively reduced by applying multiple medicinal chemistry strategies, leading to a series of PAK inhibitors that are orally active in inhibiting tumor growth in vivo.